10-DEBC HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Biologische Aktivit?t
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells.
10-DEBC HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte