2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-

Chlortetracycline hydrochloride Struktur

64-72-2

CAS-Nr.: 64-72-2

Bezeichnung:: 2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-

Englisch Name:: Chlortetracycline hydrochloride

Synonyma:: CHLORTETRACYCLINE HCL;CTC;AUREOMYCIN;CHLOROTETRACYCLINE HYDROCHLORIDE;CHLOROTETRACYCLINE HCL;AUREOMYCIN HYDROCHLORIDE;u-6780;nsc-13252;Auxeomycin;Isphamycin

CBNumber:: CB9737862

Summenformel:: C22H24Cl2N2O8

Molgewicht:: 515.34

MOL-Datei:: 64-72-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 392

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Eigenschaften

Schmelzpunkt:: 210-215 °C (dec.)(lit.)

alpha: D23 -240°

storage temp.: Inert atmosphere,Store in freezer, under -20°C

L?slichkeit: 1 M NaOH: soluble50mg/mL

Aggregatzustand: Powder

Farbe: faint yellow to yellow

pka: 3.3(at 25℃)

Wasserl?slichkeit: Soluble in water

Sensitive: Light Sensitive

Merck: 13,2211

BRN: 3858364

CAS Datenbank: 64-72-2(CAS DataBase Reference)

EPA chemische Informationen: Chlortetracycline hydrochloride (64-72-2)

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

Kennzeichnung gef?hrlicher	Xi
R-S?tze:	36/37/38
S-S?tze:	26-36
WGK Germany	2
RTECS-Nr.	QI7800000
HazardClass	3
HS Code	29413020
Toxizit?t	LD50 orally in rats: 10300 mg/kg (Goldenthal)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H317	Kann allergische Hautreaktionen verursachen.	Sensibilisierung der Haut	Kategorie 1A	Warnung	src="/GHS07.jpg" width="20" height="20" />	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizit?t (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P202	Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261	Einatmen von Staub vermeiden.
P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352	BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313	BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.

Chemische Eigenschaften

Yellow Solid

Verwenden

Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Allgemeine Beschreibung

Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.

l?uterung methode

Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Hydrogenchlorid Strke 2-Aminopteridin-4(3H),6(5H)-dion

Downstream Produkte

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 392)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12835	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	294	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	852	58
Henan Suikang Pharmaceutical Co.,Ltd.	+86-18239973690 +86-18239973690	sales@suikangpharm.com	China	311	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	2691	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58

64-72-2(2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-)Verwandte Suche:

Selendioxid 4-Dimethylamino-benzaldehyd N,N-Dimethyl-1,3-diaminopropan N,N-Dimethylpyridin-4-amin 4-Dimethylaminobenzoesure 1,4-Dioxan Topotecan hydrochloride Chlortetracyclin Clindamycinhydrochlorid Isonyl 5-Chlorsalicylaldehyd Heptaminolhydrochlorid 1,2,3,4-Tetrahydro-4-methylnaphthalin-1-on 1,2,3,4-Tetrahydro-1-naphthalinon alpha-Tetralol (2E,6Z)-Nona-2,6-dien-1-al Chlordifluormethan 2-Dimethylaminoethanol

7-CHLORTETRACYCLINE MONOHYDROCHLORIDE
7-CHLOROTETRACYCLINE HCL
7-CHLOROTETRACYCLINE HYDROCHLORIDE
7-CHLOROTETRACYCLINE MONOHYDROCHLORIDE
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-
CHLOROTETRACYCLINE HYDROCHLORIDEVETRANAL , 250 MG
CHLORTETRACYCLINE HYDROCHLORIDE FROM STR EPTOMYCES AUREOFACI
Aureociclina, Isphamycin
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride
6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-ydro-monohydrochloride
Aureociclina
Aureocycline
Auxeomycin
chlortetracyclinehydrochloride’canbeusedassecondarystandard’
clorotetraciclinacloridrato
Isphamycin
nsc-13252
u-6780
CHLORTETRACYCLINE HYDROCHLORIDE
AUREOMYCIN HCL
AUREOMYCIN(TM)
[4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
2-NaphthacenecarboxaMide, 7-chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
Chlorotetracy
Chlorterracycline Hydrochloride
Chlortetracycline hydrochloride Solution, 100ppm
Chlortetracycline for system suitability
Aureomycin/Chlortetracycline hcl
7-Chlorotetracycline hydrochloride CTC
CHLORTETRACYCLINEHYDROCHLORIDE,CRYSTAL
Auxeomycin hydrochloride.
Chlortetracycline Hc1
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride
4-Chlorotetracycline hydrochloride
Fermycin Soluble
Biomycin hydrochloride
CHLORTETRACYCLINE.HYDROCHLORIDERESEARCH GRADE
Chlortetracycline hydrochloride, conforms to Eur. Ph.
Chlortetracycline hydrochloride,7-Chlorotetracycline hydrochloride
Chlortetracycline Hydrochloride (200 mg)
Chlortetracycline Hydrochloride (200 mg)K0C1851008ug/mg(ai)
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-2-naphthacenecarboxaMide Hydrochloride
AureoMycin Monohydrochloride
Aureovit 12C80
Aurofac 100
ChlortetracycliniuM Chloride
Chlortetracycline hydrochlorideCTC
7-Chlortetracycline hydrochloride, NSC 13252
Chlortetracycline hydrochloride, potency 900 ug/mg
Chlortetracycline Hydrochloride Standard
Chlortetracycline-d6 HCl
Tetracycline Chloro HCl
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
Chlortetracycline hydrochloride USP/EP/BP
ANALYSIS REPORT OF CTC FEED GRADE
Chlortetracycline hydrochloride / Chlortetracycline hcl
Chlortetracyclin hydrochloride

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