Sunitinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC₅₀ values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC₅₀s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.

Chemische Eigenschaften

Yellow Solid

Verwenden

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Charakteristisch

Class: receptor tyrosine kinase
Treatment: RCC, GIST
Elimination half-life = 70 h
Protein binding = 95%

Sunitinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Sunitinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15361	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5858	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Jinan Million Pharmaceutical Co., Ltd	0531-68659554 +8613031714605	info@millionpharm.com	China	251	58
Binzhou Lista Trading Limited		sallychris2021@gmail.com	China	74	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55

557795-19-4()Verwandte Suche:

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• SU-11248
• N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2- dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
• N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Malate
• N-[2-DiethylaMino(ethyl-d4)]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide
• SU-11248-d4
• Sutent-d4
• (Z)-N-(2-(DiethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide
• Sunitinib (Mixture of E and Z IsoMer)
• Sunitinib N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
• Sunitinib, >=99%
• sunitinib
• SUNITINIB-D4
• n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide
• 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
• SUNITINIBMALEATE(FORR&DONLY)
• Sunitinib--- free base
• Sunitinib，Sutent
• 5-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N-(2-diethylaminoethyl)amide
• Suniti
• N-[2-(diethylaMino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]Methyl}-2,4-diMethyl-1H-pyrrole-3-carboxaMide
• SUTENT SUNITINIB
• N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)meth yl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
• Sunitinib malate(TINIBS)
• Sunitinib malate for research
• N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Maleate
• SUNITINIB (SU 11248)
• SU-11248;SU11248
• Sunitinib (Sutent, SU11248)
• SNTI
• (Z)-N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3-indolinylidene)methyl]-2,4-dimethylpyrrole-3-carboxamide
• (Z)-Sunitinib
• Sunitinib USP/EP/BP
• Sunitinib DISCONTINUED
• Sunitinib free base (SU-11248)
• SunitinibQ: What is Sunitinib Q: What is the CAS Number of Sunitinib Q: What is the storage condition of Sunitinib Q: What are the applications of Sunitinib
• SUNITINIB MALEATE
• SUNITINIB BASE
• Sutent, Sunitinib, SU11248
• Sutini
• 557795-19-4
• 41031-54-7
• C22H27FN4O2C4H6O5
• C26H33FN4O7
• C26H31FN4O6
• C22H27N4O2C4H6O5
• 26H31FN4O6
• SU-11248
• Inhibitors
• anti-neoplastic
• Heterocycles
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Sunitinib
• Molecular Targeted Antineoplastic
• Heterocyclic Compounds
• Pharmaceutical intermediate
• API
• Tyrosine Kinase Inhibitors