DIETHYLPHOSPHONOACETIC ACID
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- CAS-Nr.
- 3095-95-2
- Englisch Name:
- DIETHYLPHOSPHONOACETIC ACID
- Synonyma:
- 2-(diethoxyphosphoryl)acetic acid;NSC 272281;Diethyl sulfonic acid;Venadaparib Impurity 39;Mirogabalin Impurity 60;acetyl diethyl phosphate;Diethylphosphoacetic acid;(diethoxyphosphoryl)acetate;DIETHYLPHOSPHONOACETIC ACID;2-diethoxyphosphorylacetate
- CBNumber:
- CB9724914
- Summenformel:
- C6H13O5P
- Molgewicht:
- 196.14
- MOL-Datei:
- 3095-95-2.mol
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DIETHYLPHOSPHONOACETIC ACID Eigenschaften
- Siedepunkt:
- 150 °C/0.05 mmHg (lit.)
- Dichte
- 1.220 g/mL at 25 °C (lit.)
- Brechungsindex
- n20/D 1.445(lit.)
- Flammpunkt:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Aggregatzustand
- Viscous Liquid
- pka
- 3.48±0.10(Predicted)
- Farbe
- Clear colorless to yellow
- Wichte
- 1.220
- InChI
- InChI=1S/C6H13O5P/c1-3-10-12(9,11-4-2)5-6(7)8/h3-5H2,1-2H3,(H,7,8)
- InChIKey
- DVQMPWOLBFKUMM-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CP(OCC)(OCC)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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DIETHYLPHOSPHONOACETIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Diethylphosphonoacetic Acid (DPA) is a Horner-Wadsworth-Emmons (HWE) reagent. The mixed anhydride of trifluoroacetic acid—diethylphosphonoacetic acid Treat a 21-hydroxy-20-keto steroid leads directly to cardenolides by an intramolecular Horner-Emmons reaction. It could also used as a dummy template to prepare a molecularly imprinted polymer for use as an artificial receptor for organophosphorus pesticides (OPPs)[1-3].
Chemische Eigenschaften
clear colorless to yellow viscous liquid
Verwenden
Diethylphosphonoacetic Acid is a reagent that is used for enantioselective preparation of α-phosphoryl-α,β-unsatd.-δ-aryl-δ-lactones from nonracemic β-hydroxyaldehydes and their conversion to α-methylene-δ-aryl-δ-lactones.
Vorbereitung Methode
Diethylphosphonoacetic acid is synthesised using triethyl phosphonoacetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
After dissolving triethyl phosphonoacetate (1.7 g, 7.5 mmol) in ethanol / water (15 mL ie 14: 1) at room temperature, potassium hydroxide (424.2 mg, 7.56 mmol, ) 6597-4400) was added and stirred at room temperature. The reaction was neutralized with 1N HCl to pH 4, the ethanol was removed by distillation under reduced pressure, diluted with chloroform (20 mL), washed with water (10 mL) and saturated brine (10 mL). The separated organic layer was dried over anhydrous sodium sulfate, filtered and distilled under reduced pressure to obtain 2-(diethoxyphosphoryl)acetic acid 4 (1.48 gm, 100percent).
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 4534, 1980
DOI: 10.1021/ja00533a047
DIETHYLPHOSPHONOACETIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DIETHYLPHOSPHONOACETIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 239)Lieferanten
3095-95-2()Verwandte Suche:
- DIETHYLPHOSPHONOACETIC ACID
- DIETHYLPHOSPHONOETHANOIC ACID
- (DIETHOXYPHOSPHINOYL)ACETIC ACID
- DIETHYLCARBOXYMETHYLPHOSPHONATE
- Diethylcarboxymethylphosphonate, 98 %
- (diethoxyphosphoryl)acetate
- (Diethoxyphosphinyl)acetic acid
- 2-(Diethoxyphosphinyl)acetic acid
- Diethylphosphonoacetic acid,98%
- (Diethoxyphosphoryl)acetic acid, Diethylphosphonoacetic acid
- Diethyl (hydroxycarbonylmethyl)phosphonate
- acetyl diethyl phosphate
- Diethylphosphonoacetic acid, 98% 25GR
- Diethoxyphosphorylacetic acid
- Diethyl carboxymethanephosphonate
- Phosphono-acetic acid P,P-diethyl ester
- Acetic acid,2-(diethoxyphosphinyl)-
- Diethylphosphonoacetic acid 95%
- NSC 272281
- 2-diethoxyphosphorylacetate
- Diethylphosphoacetic acid
- DIETHYLPHOSPHONOACETIC ACID(3095-95-2)
- 2-diethoxyphosphorylaceticaci
- Diethyl sulfonic acid
- 2-(diethoxyphosphoryl)acetic acid
- Venadaparib Impurity 39
- Mirogabalin Impurity 60
- 3095-95-2
- 3095-95-5
- C6H13O5P
- C2H5O2POCH2CO2H
- Synthetic Reagents
- Olefination
- Horner-Wadsworth-Emmons Reagents
- C-C Bond Formation
- Horner-Wadsworth-Emmons Reagents
- Olefination
- C-C Bond Formation
