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Chlormadinonacetat

Chlormadinone acetate  Struktur
302-22-7
CAS-Nr.
302-22-7
Bezeichnung:
Chlormadinonacetat
Englisch Name:
Chlormadinone acetate
Synonyma:
CMA;Chlormadinone;CHLOROMADINON 17-ACETATE;17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione;6-Chloro-3,20-dioxopregna-4,6-dien-17-yl acetate;Cero;st155;Retex;ST 155;Verton
CBNumber:
CB9673089
Summenformel:
C23H29ClO4
Molgewicht:
404.93
MOL-Datei:
302-22-7.mol

Chlormadinonacetat Eigenschaften

Schmelzpunkt:
212°C
alpha 
D +6° (c = 1 in CHCl3)
Siedepunkt:
512.5±50.0 °C(Predicted)
Dichte
1.1345 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
L?slichkeit
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
Off-White to Light Yellow
maximale Wellenl?nge (λmax)
285nm(EtOH)(lit.)
Merck 
14,2102
BRN 
2633614
NIST chemische Informationen
Chlormadinone acetate(302-22-7)
EPA chemische Informationen
Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro- (302-22-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60-61-40-48
S-S?tze: 53-22-36/37/39-45
WGK Germany  3
RTECS-Nr. TU3750000
HS Code  29372390
Giftige Stoffe Daten 302-22-7(Hazardous Substances Data)
Toxizit?t mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Chlormadinonacetat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R61:Kann das Kind im Mutterleib sch?digen.
R40:Verdacht auf krebserzeugende Wirkung.
R48:Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Chlormadinone acetate is a synthetic progestin. It binds to progesterone, androgen, and glucocorticoid receptors in vitro (Kis = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 μg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.

Chemische Eigenschaften

Crystalline Solid

Weltgesundheitsorganisation (WHO)

Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)

Sicherheitsprofil

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human maternal and reproductive effects by ingestion, intramuscular, and possibly other routes: ovary, uterus, cervix, vagina, and fallopian tube changes; menstrual cycle changes or disorders; changes in ferthty; and other unspecified female effects. A human teratogen that causes developmental abnormalities of the endocrine system in the fetus. Experimental teratogenic and reproductive effects. An oral contraceptive. When heated to decomposition it emits toxic fumes of Cl-.

Chlormadinonacetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlormadinonacetat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 322)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12795 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
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+undefined17712220823
admin@guyunchem.com China 615 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2524 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
CHINA 964 58

302-22-7(Chlormadinonacetat)Verwandte Suche:


  • skeduletm
  • ST 155
  • st155
  • synchrosyn
  • Synchrosyn P
  • synchrosynp
  • Traslan
  • Verton
  • Clormadinoneacetate
  • chloromadinone 17-acetate
  • 6-Chloro-17-acetoxy-4,6-pregnadiene-3,20-dione
  • 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione, 6-Chloro-6-dehydro-17α-acetoxyprogesterone, Gestafortin, Matrol, Menstridyl, 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate
  • 17-alpha-acetoxy-
  • Chlormadinone acetate,17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione, 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate, 6-Chloro-6-dehydro-17α-acetoxyprogesterone, Gestafortin, Matrol, Mens
  • (8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-diMethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • Chlormadinone Acetate Solution, 100ppm
  • 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate
  • 6-Chloro-6-dehydro-17α-acetoxyprogesterone
  • 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione
  • 17-Acetoxy-6-chloro-6-dehydroprogesterone
  • 17-alpha-Acetoxy-6-chloro-6,7-dehydroprogesterone
  • 17-alpha-acetoxy-6-chloro-6-dehydroprogesterone
  • 17alpha-Acetoxy-6-chloro-6-dehydroprogesterone
  • 17-alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione
  • 17alpha-Acetoxy-6-chloropregna-4,6-diene-3,20-dione
  • 20-dione,17-(acetoxy)-6-chloro-pregna-6-diene-3
  • 6-chloro-delta(sup6)-(17-alpha)acetoxyprogesterone
  • 6-chloro-delta(sup6)-17-acetoxyprogesterone
  • 6-chloro-delta(sup6)-dehydro-17-acetoxyprogesterone
  • 6-Chloro-delta4,6-pregnadiene-17alpha-ol-3,20-dione 17-acetate
  • 6-Chloro-delta6-17-acetoxyprogesterone
  • 6-Chloro-delta6-dehydro-17-acetoxyprogesterone
  • 6-Chloro-delta6-(17alpha)acetoxyprogesterone
  • 6-Chloro-delta-6-17alpha-hydroxyprogesterone acetate
  • 6-Chloro-pregna-4,6-dien-17alpha-ol-3,20-dione acetate
  • 6-chloro-pregna-4,6-dien-17-alpha-ol-3,20-dioneacetate
  • 6-Dehydro-6-chloro-17-alpha-acetoxyprogesterone
  • 6-diene-3,20-dione,6-chloro-17-hydroxy-pregna-acetate
  • Ay 13390-6
  • ay13390-6
  • Bovisynchron
  • Cero
  • Chloramdinone acetate
  • 6-chloro-17-alpha-acetoxy-4,6-pregnadiene-3,20-dione
  • 6-Chloro-17alpha-acetoxy-4,6-pregnadiene-3,20-dione
  • 6-chloro-17-alpha-hydroxy-delta(sup6)-progesteroneacetate
  • 6-Chloro-17alpha-hydroxy-delta6-progesterone acetate
  • 6-Chloro-17alpha-hydroxypregna-4,6-diene-3,20-dione acetate
  • 6-chloro-17-alpha-hydroxypregna-4,6-diene-3,20-dioneacetate
  • 6-Chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate
  • 6-Chloro-6-dehydro-17alpha-hydroxyprogesterone acetate
  • 6-chloro-6-dehydro-17-alpha-hydroxyprogesteroneacetate
  • 6-chloro-delta(sup4,6)-pregnadiene-17-alpha-ol-3,20-dione17-acetate
  • CHLOROMADION 17-ACETATE VETRANAL, 100 MG
  • 17ALPHA-ACETOXY-6-CHLORO-4,6-PREGNADIENE-3,20-DIONE
  • MATROL
  • MENSTRIDYL
  • GESTAFORTIN
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