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CHK2 INHIBITOR II

CHK2 INHIBITOR II Struktur
516480-79-8
CAS-Nr.
516480-79-8
Englisch Name:
CHK2 INHIBITOR II
Synonyma:
C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;C 3742 BML-277;BML-277 (C 3742);Chk2 Inhibitor II hydrate;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II (BML-277)
CBNumber:
CB9503256
Summenformel:
C20H14ClN3O2
Molgewicht:
363.8
MOL-Datei:
516480-79-8.mol

CHK2 INHIBITOR II Eigenschaften

Siedepunkt:
637.1±63.0 °C(Predicted)
Dichte
1.390±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: 18 mg/mL
Aggregatzustand
solid
pka
10.40±0.10(Predicted)
Farbe
tan
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

CHK2 INHIBITOR II Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.

Verwenden

Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).

Biochem/physiol Actions

Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).

CHK2 INHIBITOR II Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CHK2 INHIBITOR II Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 103)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29879 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574
 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58

516480-79-8()Verwandte Suche:

  • C 3742
  • BML-277
  • 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
  • 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxylic acid amide
  • C 3742 BML-277
  • InSolution? Chk2 Inhibitor II
  • 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide
  • 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
  • Chk2 Inhibitor II hydrate
  • 2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE, >98%
  • BML-277, >98%
  • BML-277 (C 3742)
  • CS-1761
  • BML-277,CHK2 INHIBITOR II
  • CHK2 INHIBITOR II; C 3742; BML277; BML 277
  • Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
  • InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
  • 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
  • Chk2 Inhibitor II (BML-277)
  • 1H-Benzimidazole-6-carboxamide, 2-[4-(4-chlorophenoxy)phenyl]-
  • 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-6-carboxamide
  • inhibit,Checkpoint Kinase (Chk),Inhibitor,BML277,BML-277,Apoptosis
  • Chk2InhibitorⅡ
  • 516480-79-8
  • Inhibitors
  • API
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