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AR-A014418

AR-A014418 Struktur
487021-52-3
CAS-Nr.
487021-52-3
Englisch Name:
AR-A014418
Synonyma:
SN 4521;CS-1021;AR 014418;AR 0133418;AR-AO 14418;AR-A014418-D3;GSK 3β inhibitor;AR-A014418, >=98%;AR-A014418 (SN-4521;AR-A014418/ARA014418
CBNumber:
CB9497883
Summenformel:
C12H12N4O4S
Molgewicht:
308.31
MOL-Datei:
487021-52-3.mol

AR-A014418 Eigenschaften

Schmelzpunkt:
208-210?C (dec.)
Dichte
1.464±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥20mg/mL, clear, light yellow
Aggregatzustand
Yellow solid
pka
5.80±0.70(Predicted)
Farbe
off-white to tan
Sensitive 
Light Sensitive
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-37/38-41
S-S?tze: 26-36/39
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

AR-A014418 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augensch?den.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/39:Bei der Arbeit geeignete Schutzkleidung und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

Pale Yellow Solid

Verwenden

AR-A014418 has been used as an inhibitor of glycogen synthase kinase 3 (GSK3).

Allgemeine Beschreibung

A cell-permeable thiazole-containing urea compound that acts as a potent inhibitor of GSK-3. Shown to inhibit GSK-3β with high potency (IC50 = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38 nM). Specificity has been reported using a panel of 28 different kinases, including Cdk2 and Cdk5 (IC50 >100 μM). Shown to prevent tau phosphorylation at a GSK-3-specific site. Also shown to protect neuronal cells against Aβ-mediated neurodegeneration in vitro and reduce tauopathy in mice in vivo (30 μmol/kg delivered with 40% PEG400 and 40% dimethylacetamide in water). Caution: Do not use delivering vehicles containing dimethylamine for in vivo studies, as it is highly toxic to animals. A 25 mM (5 mg/649 μl) solution of GSK-3β Inhibitor VIII (Cat. No. 361557) in DMSO is also available.

Enzyminhibitor

This ATP-competitive protein kinase inhibitor (FW = 308.31 g/mol; CAS 487021-52-3; Solubility: 62 mg/mL DMSO; <1 mg/mL H2O) selectively targets glycogen synthase kinase 3β (GSK3β),with IC50 = 104 nM; Ki = 38 nM. Attesting to its high specificity for GSK3, AR-A014418 does not significantly inhibit Cdk2 or Cdk5 (IC50 > 100 μM) or 26 other kinases. AR-A014418 inhibits phosphorylation of the microtubule-associated protein Tau at Ser-396 (i.e., the GSK3-specific site) in cells stably expressing human four-repeat Tau. AR-A014418 protects N2A neuroblastoma cells against cell death mediated by inhibition of the phosphatidylinositol 3-kinase/protein kinase B survival pathway. AR- A014418 inhibits neurodegeneration mediated by b-amyloid peptide in hippocampal slices. Treatment of neuroblastoma cell lines with AR- A014418 reduced the level of GSK-3α phosphorylation at Tyr-279 compared to GSK-3β phosphorylation at Tyr-216, and attenuated growth via the maintenance of apoptosis.. AR-A014418-dependent antinociceptive effects are induced by modulation of the glutamatergic system through metabotropic and ionotropic (NMDA) receptors and the inhibition of TNF-α and IL-1β cytokine signaling.

AR-A014418 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AR-A014418 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 122)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32820 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32002 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896
cbc@coresyn.com China 9984 58

487021-52-3()Verwandte Suche:


  • N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea AR 0133418
  • AR 0133418
  • GSK 3B Inhibitor VIII
  • AR 014418
  • GSK 3β inhibitor
  • 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea
  • AR-A014418/ARA014418
  • SN 4521
  • AR-A014418, >=98%
  • N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
  • N-[(4-Methoxyphenyl)Methyl]-N'-(5-nitro-thiazol-2-yl)urea
  • AR-AO 14418
  • GSK-3β Inhibitor VIII
  • GSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem
  • AR-A014418(GSK3β Inhibitor VIII)
  • CS-1021
  • AR-AO 14418; AR 0133418; AR 014418; GSK 3Β INHIBITOR
  • AR-A014418-D3
  • AR 0133418;GSK 3Β INHIBITOR VIII;AR 014418
  • Urea, N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)-
  • GSK3β Inhibitor VIII
  • 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)ure
  • AR-A014418(GSK3βInhibitorVIII)
  • AR-A014418 (SN-4521
  • 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
  • 487021-52-3
  • Akt
  • mTOR
  • PI3K
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Other enzyme inhibitors and activators
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
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