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SPARSOMYCIN

SPARSOMYCIN Struktur
1404-64-4
CAS-Nr.
1404-64-4
Englisch Name:
SPARSOMYCIN
Synonyma:
U-19183;nsc59729;Aids012106;B 120121L19;Aids-012106;sparsomycin;Sparsomycin from Streptomyces sparsogenes;(E)-N-[(S)-1-(Hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidine-5-yl)propenamide;2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[(R)-[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)-
CBNumber:
CB9497025
Summenformel:
C13H19N3O5S2
Molgewicht:
361.44
MOL-Datei:
1404-64-4.mol

SPARSOMYCIN Eigenschaften

Schmelzpunkt:
208-209° (dec)
alpha 
D25 +69° (c = 0.5 in water)
Dichte
1.3893 (rough estimate)
Brechungsindex
1.6390 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
Aggregatzustand
A solid
pka
8.67 in water, 9.05 in 40% ethanol
Farbe
White to off-white

Sicherheit

Kennzeichnung gef?hrlicher T+
R-S?tze: 28
S-S?tze: 28-36/37-45
RIDADR  UN 2811 6.1/PG 2
RTECS-Nr. WG5850000
Toxizit?t LD50 in dogs, rats, mice (mg/kg): 0.5-1.0, 2.25, 4.32 i.v. (Ottenheijm, 1986); LD50 i.p. in mice: 2.4 mg/kg (Owen)

SPARSOMYCIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R28:Sehr giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.

Verwenden

Sparsomycin is an antibiotic that binds to active site and exit tunnel hydrophobic crevices of peptidyltransferase center of Haloarcula marismortui large ribosomal subunit.

SPARSOMYCIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SPARSOMYCIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19741 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
BOC Sciences 16314854226
info@bocsci.com United States 9923 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58
Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
sales@mitachieve.com China 8860 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24644 58
Hubei Enxing Biotechnology Co., Ltd 16621771607
exbio_tech@163.com China 8190 58
Shanghai Saikerui Biotechnology Co. , Ltd. 021-58000709 15900491054
info@scrbio.com China 10329 58

1404-64-4()Verwandte Suche:


  • Aids-012106
  • B 120121L19
  • nsc59729
  • sparsomycin
  • Sparsomycin from Streptomyces sparsogenes
  • (E)-N-[(S)-1-(Hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidine-5-yl)propenamide
  • U-19183
  • 2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[(R)-[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)-
  • Aids012106
  • 1404-64-4
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