4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure
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- CAS-Nr.
- 16052-06-5
- Bezeichnung:
- 4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure
- Englisch Name:
- HEPPS
- Synonyma:
- HEPE;EPPS;aEPPS;HEPPS;EPPS,99%;HEPPS(EPPS);HEPPS Buffer;EPPS USP/EP/BP;EPPS SIGMAULTRA;HEPPS ULTRAPURE
- CBNumber:
- CB9310937
- Summenformel:
- C9H20N2O4S
- Molgewicht:
- 252.33
- MOL-Datei:
- 16052-06-5.mol
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4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure Eigenschaften
- Schmelzpunkt:
- 237-239 °C(lit.)
- Dichte
- 1.2684 (rough estimate)
- Brechungsindex
- 1.6800 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- H2O: 1 M at 20 °C, clear, colorless
- Aggregatzustand
- Powder/Solid
- Farbe
- White
- PH
- 5.0-6.5 (25℃, 0.1M in H2O)
- pka
- 8.0(at 25℃)
- S?ure-Base-Indikators(pH-Indikatoren)
- 7.3 - 8.7
- Wasserl?slichkeit
- Soluble in water. 25.2 g/L (20°C)
- maximale Wellenl?nge (λmax)
- λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045
- BRN
- 3957385
- CAS Datenbank
- 16052-06-5(CAS DataBase Reference)
- EPA chemische Informationen
- 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38-22 |
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| S-S?tze: |
24/25-36-26 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TM2649130 |
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| TSCA |
Yes |
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| HazardClass |
IRRITANT |
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| HS Code |
29335995 |
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| Toxizit?t |
quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
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4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystalline powder
Verwenden
HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.
Allgemeine Beschreibung
HEPPS, or N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), is a zwitterionic buffering agent commonly used in biochemical and molecular biology research. Its mechanism of action is rooted in its ability to maintain a stable pH environment, which is crucial for various enzymatic reactions and protein studies. HEPPS is especially favoured for its buffering capacity in the physiological pH range, typically between pH 6.8 and 8.2, making it ideal for biological assays and cell culture experiments. This compound is extensively utilized in preparing cell culture media, where maintaining a consistent pH is essential for cell viability and growth. Additionally, HEPPS is employed in biochemical assays, such as enzyme kinetics studies, where precise pH control is necessary to accurately measure enzymatic activity. Furthermore, HEPPS has found applications in molecular biology techniques, including nucleic acid purification, PCR (polymerase chain reaction), and protein analysis by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). Its compatibility with various biological systems and stability under physiological conditions make HEPPS a valuable tool in research laboratories for maintaining optimal pH conditions and ensuring reliable experimental outcomes in various biochemical and molecular biology studies.
4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 358)Lieferanten
16052-06-5(4-(2-Hydroxyethyl)-1-piperazinpro-pansulfons?ure)Verwandte Suche:
- HEPPS(EPPS)
- 4-(2-Hydroxyethyl)pi
- HEPE
- 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINE]PROPANESULFONIC ACID
- 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]PROPANESULFONIC ACID
- N-(2-HYDROXYETHYL)-N'-(3-SULFOPROPYL)-PIPERAZINE
- N-[2-HYDROXYETHYL]PIPERAZINE-N'-[3-PROPANESULFONIC ACID]
- N-2-HYDROXYETHYLPIPERAZINE-N'-3-PROPANESULPHONIC ACID
- aEPPS
- HEPPS N-(2-Hydroxyethyl)piperazine-N-3-propanesulfonic acid
- HEPPS, ULTROL Grade
- HEPPS~4-(2-Hydroxyethyl)-1-piperazinepropanesulphonic acid
- EPPS FREE ACID, BIOTECHNOLOGY PERFORMANC E CERTIFIED
- EPPS, 99% (4-(2-HYDROXYETHYL)-1-PIPERAZI NE -PROPANESULFONIC ACID)
- EPPS SIGMAULTRA
- HEPPS CELL CULTURE REAGENT CRYSTALLINE
- EPPS 99% (4-(2-HYDROXYETHYL)-1-PIPERAZINE -PROPANESULFONIC ACID) 99+% ULTRA PURE BUFFER GRADE
- EPPS, for biochemistry, 99%
- Hydroxyethyl)piperazine-N'-3-propane-sulfonic acid
- 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-
- 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid
- N-(hydroxyethyl)piperazine-N’-propanesulfonic acid (HEPPS)
- 4-(2-HYDROXYETHYL)-1-PIPERAZINEPROPANESULFONIC ACID EPPS
- HEPPS ULTRAPURE
- HEPPS (4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID)
- 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid
- HEPPS/EPPS/HEPE
- 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid[HEPPS]
- HEPPS
3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid
- 4-Hydroxyerhylpiperazine-1-propanesulfonic acid
- EPPS,99%
- EPPS Vetec(TM) reagent grade, 99%
- HEPPS/ 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid
- 4-(2-hydroxyethyl)-1-piperazinepropanesulfonicaci
- EPPS
- HEPPS
- LABOTEST-BB LT00138110
- 4-(2-HYDROXYETHYL)-1-PIPERAZINEPROPANESULFONIC ACID
- 4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID
- N-(2-Hydroxyethyl)piperazine-N'-3-propanesulphonic acid >99%
- 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component for biological research]
- Epps, 99%, for biochemistry
- HeppsN-(2-Hydroxyethyl)Piperazine-NPropanesulfonicAcid
- Epps(N-[2-Hydroxyethyl]Piperazine-N3-PropaneSulfonicAcid])
- 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid
- 3-[4-(2-Hydroxyethyl)piperazine-1-yl]-1-propanesulfonic acid
- 3-[4-(2-Hydroxyethyl)piperazino]-1-propanesulfonic acid
- 4-(2-Hydroxyethyl)-1-piperazinepropane-1-sulfonic acid
- HEPPS Buffer
- 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, HEPPS, N-(2-Hydroxyethyl)piperazine-Nμ-(3-propanesulfonic acid)
- 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
- [2-hydroxyethyl]piperazine-n’-[3-propancesulfonicacid]
- N-(Hydroxyethyl)piperazine-N'-propane sulfonic acid
- 3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic
- N-(2-Hydroxyethyl)piperazine-N'-(propanesulphonic acid)
- HEPPS, ≥99.0%(T)
- HEPPS, ≥99.5%(T)
- 4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID;EPPS
