成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Larotrectinib Sulfate

Larotrectinib Sulfate Struktur
1223405-08-0
CAS-Nr.
1223405-08-0
Englisch Name:
Larotrectinib Sulfate
Synonyma:
LOX-101;Loxo-101（S）;LOX-101(sulfate);ARRY 470) sulfate;Larotinib sulfate;LOXO-101 (sulfate);Larotrectinib sulfate;Larotrectinib(LOXO 101;ARRY-470, Larotrectinib;Larotrectinib sulfate salt
CBNumber:
CB93067010
Summenformel:
C21H24F2N6O6S
Molgewicht:
526.52
MOL-Datei:
1223405-08-0.mol

Larotrectinib Sulfate Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
≥18.47 mg/mL in DMSO; ≥2.14 mg/mL in EtOH; ≥29.65 mg/mL in H2O
Aggregatzustand
solid
Farbe
Light yellow to brown
Stabilit?t:
Hygroscopic
InChIKey
PXHANKVTFWSDSG-RZOMTXEQNA-N
SMILES
S(O)(O)(=O)=O.FC1C=CC(F)=CC=1[C@H]1CCCN1C1C=CN2N=CC(NC(N3C[C@@H](O)CC3)=O)=C2N=1 |&1:13,29,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Larotrectinib Sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LOXO-101 (sulfate) (or Larotrectinib Sulfate) is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons.

Verwenden

Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).

Larotrectinib Sulfate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

4H-Pyrazolo[1,5-a]pyrimidin-5-one (S)-3-Hydroxypyrrolidine 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole 3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one LOXO-101 (S)-3-Hydroxypyrrolidine hydrochloride (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE 2-Brom-1,4-difluorbenzol

Downstream Produkte

Larotrectinib Sulfate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 184)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhengzhou Anhuida Chemical Co., Ltd
+8615903659408
 admin@ahdchem.com China 286 58
Beijing Hope Pharmaceutical Co., Ltd.
+86-010-67886402 +8613611125266
 market@hopelife.cn China 72 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 456 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Ningbo Nuobai Pharmaceutical Co., Ltd. 		18758416982
Fisheryu@nbpharm.com China 13 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018
ramyan@ex-biotech.com CHINA 954 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29811 58
  • LOXO-101 (sulfate)
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate (1:1)
  • Larotrectinib/LOXO 101/ARRY 470 sulfate
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate
  • ARRY 470) sulfate
  • Larotrectinib sulfate
  • Larotrectinib(LOXO 101
  • Larotrectinib (LOXO-101) sulfate
  • 1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-, sulfate (1:1)
  • ARRY-470, Larotrectinib
  • LOX-101
  • Loxo-101（S）
  • LOX-101(sulfate)
  • Larotrectinib sulfate（LOXO101）
  • (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate
  • Larotrectinib sulfate salt
  • 2H4]-Larotrectinib sulfate salt
  • LOXO-101 sulfate|||Larotrectinib (LOXO-101) sulfate|||Larotrectinib|||LOXO-101 (sulfate)|||ARRY-470|||ARRY-470 (sulfate)
  • Larotinib sulfate
  • 1223405-08-0
  • C21H22F2N6O2H2SO4
  • C21H24F2N6O6S
  • API
  • LOXO-101
Copyright 2019 ? ChemicalBook. All rights reserved