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ANTI-TOPOISOMERASE I

ANTI-TOPOISOMERASE I Struktur
CAS-Nr.
Englisch Name:
ANTI-TOPOISOMERASE I
Synonyma:
ANTI-TOPOISOMERASE I;MONOCLONAL ANTI-TOPOISOMERASE I;Monoclonal Anti-Topoisomerase I antibody produced in mouse
CBNumber:
CB9276716
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-TOPOISOMERASE I Eigenschaften

storage temp. 
−20°C
Aggregatzustand
buffered aqueous solution
Biologische Quelle
mouse

Sicherheit

WGK Germany  2

ANTI-TOPOISOMERASE I Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-Topoisomerase I antibody produced in mouse has been used in western blot analysis.

Allgemeine Beschreibung

Monoclonal Anti-Topoisomerase I (mouse IgG1 isotype) is derived from the Mab1 hybridoma produced by the fusion of SP2/0 mouse myeloma cells and splenocytes from BALB/c mice immunized with human purified topoisomerase I. The protein family of DNA topoisomerases is divided into two types (type I and II). The type I enzymes include eukaryotic and bacterial topoisomerase I and III. Human DNA Topoisomerase I belong to the subtype IB enzymes. The protein has four distinct domains. There are four nuclear localization signals in the N-terminal domain. A linker domain of 77 amino acids follows the core domain. The fourth domain, which is 53 amino acids long, contains the active site Tyr723. Topoisomerase I (TOP1) gene is located on human chromosome 20q12.

Biochem/physiol Actions

DNA topoisomerases are enzymes that control the amount of supercoiling in DNA. Without topoisomerases, DNA cannot replicate normally. Type I enzymes of DNA topoisomerases introduce transient single strand breaks in DNA. Recently it was reported that DNA topoisomerase I is involved in modulation of RNA and is present in retroviral particles, like human immunodeficiency virus (HIV1). Furthermore, the enzyme enhances HIV-1 cDNA production in reverse transcription assays in vitro. Topoisomerase I (TOP1) serves as swivel at the time of replication, transcription and recombination, which helps in releasing over winding of duplex DNA.

ANTI-TOPOISOMERASE I Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-TOPOISOMERASE I Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 3)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Riedel-de Haen AG --
United States 6773 87
SIGMA-RBI --
Switzerland 6896 91
Vision BioSystems --
sales.usa@vision-bio.com United States 542 74

  • ANTI-TOPOISOMERASE I
  • Monoclonal Anti-Topoisomerase I antibody produced in mouse
  • MONOCLONAL ANTI-TOPOISOMERASE I
  • MAntibodies
  • Enzymes
  • Clone Index
  • Cancer Research
  • Antibodies to Transcription RegulatorsAntibodies
  • Antibodies for Gene Regulation and Expression
  • Alphabetical Index
  • Antibodies to DNA Synthesis and Repair EnzymesCell Biology
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