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N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Struktur
164204-38-0
CAS-Nr.
164204-38-0
Englisch Name:
N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
Synonyma:
Phosphoramidon (Disodium);CRDWMOVRQCMROH-HIKRQZGHSA-N;N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt;N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1);N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
CBNumber:
CB92744622
Summenformel:
C23H35N3NaO10P
Molgewicht:
567.51
MOL-Datei:
164204-38-0.mol

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Eigenschaften

storage temp. 
Desiccate at -20°C
L?slichkeit
≥58.7 mg/mL in DMSO; insoluble in EtOH; ≥52.5 mg/mL in H2O
Aggregatzustand
solid
Farbe
White to off-white
Wasserl?slichkeit
Soluble to 100 mM in water

Sicherheit

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 μM). Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.

Verwenden

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
  • Phosphoramidon (Disodium)
  • CRDWMOVRQCMROH-HIKRQZGHSA-N
  • N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
  • N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
  • 164204-38-0
  • C23H34N3Na2O10P
  • Inhibitors
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