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Rho Kinase Inhibitor V

Rho Kinase Inhibitor V Struktur
1072906-02-5
CAS-Nr.
1072906-02-5
Englisch Name:
Rho Kinase Inhibitor V
Synonyma:
Rho Kinase Inhibitor V;Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem;1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]-
CBNumber:
CB92645099
Summenformel:
C18H15N3O3
Molgewicht:
321.33
MOL-Datei:
1072906-02-5.mol

Rho Kinase Inhibitor V Eigenschaften

Siedepunkt:
638.4±55.0 °C(Predicted)
Dichte
1.374±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
Aggregatzustand
Light beige solid
pka
12.53±0.70(Predicted)

Sicherheit

Rho Kinase Inhibitor V Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC50 = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC50 = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC50 = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations.

Rho Kinase Inhibitor V Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Rho Kinase Inhibitor V Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 15)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80

  • Rho Kinase Inhibitor V
  • Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem
  • 1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]-
  • 1072906-02-5
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