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Fluoxymesteron

Fluoxymesterone Struktur
76-43-7
CAS-Nr.
76-43-7
Bezeichnung:
Fluoxymesteron
Englisch Name:
Fluoxymesterone
Synonyma:
Halotestin;Halo;ora-testryl;Fluoxymestrone;Fluoxymesteron;FluoxyMesterone(Halotestin);Halotestin(Fluoxymesterone);9α-Fluoro-11β-hydroxy-17-methyltestosterone;FXM;u6040
CBNumber:
CB9258118
Summenformel:
C20H29FO3
Molgewicht:
336.44
MOL-Datei:
76-43-7.mol

Fluoxymesteron Eigenschaften

Schmelzpunkt:
240 °C
alpha 
104 º (c=1,EtOH)
Siedepunkt:
474.2±45.0 °C(Predicted)
Dichte
1.0455 (estimate)
storage temp. 
-20°C
L?slichkeit
H2O: ≤0.5 mg/mL
Aggregatzustand
solid (photosensitive)
pka
13.40±0.70(Predicted)
Farbe
white
Wasserl?slichkeit
NEGLIGIBLE
Merck 
13,4212
InChI
InChI=1/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/s3
InChIKey
YLRFCQOZQXIBAB-MGWAJYFFNA-N
SMILES
[C@]12(F)[C@@H](O)C[C@]3(C)[C@](CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)(O)C |&1:0,2,5,7,10,12,22,r|
CAS Datenbank
76-43-7(CAS DataBase Reference)
NIST chemische Informationen
4-Androsten-3-one, 9alpha-fluoro-11beta,17beta-dihydroxy-17alpha-methyl-,(76-43-7)
EPA chemische Informationen
Fluoxymesterone (76-43-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,T,F
R-S?tze: 63-38-19-11-61-60
S-S?tze: 22-36-24/25-45-53
WGK Germany  3
RTECS-Nr. BV8390000
HS Code  29372900
Giftige Stoffe Daten 76-43-7(Hazardous Substances Data)
Toxizit?t LD50 intraperitoneal in mouse: 2350mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Fluoxymesteron Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Fluoxymesterone(Halotestin) is a steroid with an androgenic property that is used in primary hypogonadism and testicular failure due to cryptorchidism, vanishing testes syndrome, or orchidectomy; and in hypogonadotrophic hypogonadism and luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary hypothalamic injury from tumors, trauma, or radiation. It mimics the actions of testosterone, which is responsible for normal growth and development of the male sex organs and for the maintenance of secondary sex characteristics. In female postmenopausal patients, fluoxymesterone may be indicated in the palliation of recurrent mammary cancer.

Chemische Eigenschaften

white to light yellow crystal powder

Verwenden

Fluoxymesterone is an anabolic steroid with androgenic activity. It is used in the treatment of male hypogonadism. It showed antitumor effects on pregnancy-dependent mammary tumors TPDMT-4.

Indications

Fluoxymesterone promotes growth and development of male reproductive organs, maintains secondary sex characteristics, increases protein anabolism, and decreases protein catabolism. It is used to treat symptoms of low testosterone in adult men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). It is also used for palliation of androgen-responsive recurrent mammary cancer in women who are more than 1 year but less than 5 years postmenopausal (women).

Definition

ChEBI: Fluoxymesterone is an anabolic androgenic steroid, a 17beta-hydroxy steroid, an 11beta-hydroxy steroid, a fluorinated steroid and a 3-oxo-Delta(4) steroid. It has a role as an antineoplastic agent and an anabolic agent.

Allgemeine Beschreibung

Fluoxymesterone, 9α-fluoro-11β,17β-dihydroxy-17-methylandrost-4-en-3-one, is ahighly potent, orally active androgen, about 5 to 10 timesmore potent than testosterone. It can be used for all theindications discussed previously, but its great androgenicactivity has made it useful primarily for treatment of theandrogen-deficient male.

Mechanism of action

Fluoxymesterone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, fluoxymesterone binds to the androgen receptor. It produces retention of nitrogen, sodium, potassium, and phosphorus, increases protein anabolism, decreases amino acid catabolism and decreases urinary excretion of calcium. The antitumour activity of fluoxymesterone appears related to the reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.

Pharmakokinetik

By substituting a 9α-fluoro group onto an analog of 17α-methyltestosterone, fluoxymesterone has 20 times the anabolic and 10 times the androgenic activity of 17α-methyltestosterone. It has a mean half-life of 9 hours, and less than 5% of the drug is excreted unchanged. An adverse effect of fluoxymesterone is sodium and water retention that could lead to edema.

Sicherheitsprofil

Fluoxymesterone is contraindicated in male subjects with known or suspected carcinoma of the prostate gland. Prolonged use of high-dosage 17-alpha-alkyl androgens is known to have caused hypercalcemia, hepatic adenoma, hepatocellular carcinoma, and hepatitis. Fluoxymesterone, which accelerates bone maturation without producing linear growth, should be used cautiously in males with delayed puberty. Edema and CHF may occur in patients with preexisting cardiovascular problems. Androgens cause virilization in female subjects.

Fluoxymesteron Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fluoxymesteron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 203)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhengzhou Hanke Import and export Trade Co. LTD
+8613838064731
sales1@zzybchem.com China 66 58
Hebei Anda Technology Co., LTD
+86-19831998802
106@hebeianda.cn China 278 58
Hubei Lange Biotechnology Co., Ltd.
+8617762501948
sales2@langebiotech.com China 153 58
Hebei Nafu Technology Co. , Ltd.
+8615075022224
17745771666@hebeinafu.com China 308 58
Doublewin Biological Technology Co., Ltd
+86-19971437628
doublewin-bella@nandrolonesteroid.com China 97 58
Wuhan Quanjinci New Material Co.,Ltd.
+86-15271838296; +8615271838296
kyra@quanjinci.com China 1512 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580 +86-13176845580
da@zhongda-biotech.com China 232 58
Anhui Zhongda Biotechnology Co., Ltd
+8619956560829
justine@zhongda-biotech.com China 286 58

76-43-7(Fluoxymesteron)Verwandte Suche:


  • 11-beta,17-beta-Dihydroxy-9-alpha-fluoro-17-alpha-methyl-4-androster-3-one
  • 17-alpha-methyl-9-alpha-fluoro-11-beta-hydroxytesterone
  • 17-alpha-Methyl-9-alpha-fluoro-11-beta-hydroxytestosterone
  • 9-alpha-fluoro-11-beta,17-beta-dihydroxy-17-alpha-methyl-4-androstene-3-one
  • 9alpha-Fluoro-11beta,17beta-dihydroxy-17alpha-methyl-4-androstene-3-one
  • 9-alpha-fluoro-11-beta-hydroxy-17-methyltestosterone
  • 9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone
  • 9-alpha-Fluoro-17-alpha-methyl-11-beta,17-dihydroxy-4-androsten-3-one
  • Flusteron
  • Flutestos
  • FXM
  • Neo-Ormonal
  • NSC-12165
  • Ora Testryl
  • Oralsterone
  • Oratestin
  • oratestryl
  • Testoral
  • Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-
  • U 6040
  • u6040
  • Ultandren
  • Ultandrene
  • 11BETA,17BETA-DIHYDROXY-9ALPHA-FLUORO-17ALPHA-METHYL-4-ANDROSTEN-3-ONE
  • Fluoxymesterone, 97.0-102.0%, 0%
  • Fluoxymesterone,11β,17β-Dihydroxy-9α-fluoro-17α-methyl-4-androsten-3-one, 9α-Fluoro-11β,17β-dihydroxy-17α-methylandrost-4-en-3-one, 9α-Fluoro-11β-hydroxy-17α-methyltestosterone
  • Fluoxymesterone CIII (200 mg)
  • Fluoxymesterone ON (200 mg)
  • 1,2-Dimethoxyethane (test Fluoxymesterone, 1.0 mg/mL )
  • FLUOXYMESTERONE
  • FluoxyMesterone (CIII), USP
  • Androst-4-en-3-one,9-fluoro-11,17-dihydroxy-17-Methyl-, (11b,17b)-
  • Fluoxymesterone solution
  • fluoxymesterone solution,100ppm
  • Halotesin
  • Fluoxymestron
  • 9-fluoro-11,17-dihydroxy-17-methyl-,(11-beta,17-beta)-androst-4-en-3-on
  • 9-fluoro-11,17-dihydroxy-17-methyl-,(11beta,17beta)-androst-4-en-3-on
  • 9-Fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
  • 9-fluoro-11-beta,17-beta-dihydroxy-17-methyl-androst-4-en-3-on
  • 9-fluoro-11beta,17beta-dihydroxy-17-methyl-androst-4-en-3-on
  • 9-Fluoro-11-beta,17-beta-dihydroxy-17-methylandrost-4-en-3-one
  • Androfluorene
  • Androfluorone
  • Androst-4-en-3-one, 9-fluoro-11,17-dihydroxy-17-methyl-, (11beta,17beta)-
  • Androst-4-en-3-one, 9-fluoro-11beta,17beta-dihydroxy-17-methyl-
  • Androsterolo
  • component of Halodrin
  • Fluoro-9-alpha dihydroxy-11-beta,17-beta methyl-17-alpha androstene-4 one-3
  • fluoro-9-alphadihydroxy-11-beta,17-betamethyl-17-alphaandrostene-4one-3
  • Fluosterone
  • Fluotestin
  • Fluoximesterone
  • 4-ANDROSTEN-9-ALPHA-FLUORO-17-ALPHA-METHYL-11-BETA, 17-BETA-DIOL-3-ONE
  • 9ALPHA-FLUORO-11BETA-HYDROXY-17ALPHA-METHYLTESTOSTERONE
  • 9a-fluoro-11b,17b-dihydroxy-17a-methyl-4-androsten-3-one
  • 9-alpha-fluoro-11-beta,17-beta-dihydroxy-17-alpha-methylandrost-4-en-3-one
  • fluoxymesterone standard solution
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