5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
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- CAS-Nr.
- 1224844-38-5
- Englisch Name:
- 5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
- Synonyma:
- MLN0128;INK-128;TAK-228;MLN0218;MLNO128;INK-0128;INK128, >=98%;INK 128; INK128;INK 128 (MLN0128);Sapanisertib (NK128
- CBNumber:
- CB92553620
- Summenformel:
- C15H15N7O
- Molgewicht:
- 309.33
- MOL-Datei:
- 1224844-38-5.mol
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5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine Eigenschaften
- Schmelzpunkt:
- 270-272°C (dec.)
- Siedepunkt:
- 598.8±60.0 °C(Predicted)
- Dichte
- 1.64
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 25 mg/ml)
- pka
- 3.77±0.30(Predicted)
- Aggregatzustand
- solid
- Farbe
- Off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
- InChIKey
- GYLDXIAOMVERTK-UHFFFAOYSA-N
- SMILES
- C1=NC(N)=C2C(C3=CC=C4OC(N)=NC4=C3)=NN(C(C)C)C2=N1
Sicherheit
5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC
50 = 1 nM). It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2. INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors. Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models. The effects of INK128 on gene expression also reduce invasion and metastasis.
Verwenden
3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. TORC1/2 inhibitors are mechanistically
distinct from rapamycinand offer a compelling approach to the treatment of cancer by targeting translational control, cell metabolism, growth andangiogenesis.
5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 164)Lieferanten
1224844-38-5()Verwandte Suche:
- 5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
- 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- INK-128
- 3-(2-aminobenzo[d]oxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- INK-128 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- MLN0128
- 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
- -(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine
- INK 128 (MLN0128)
- INK128, >=98%
- INK-128(Sapanisertib)
- INK-0128
- INK 128 (MLN0128),95+
- INK 128 (MLN0128);INK-128;MLN0128
- INK 128; INK128
- Sapanisertib (INK 128, MLN0128,TAK-228)
- TAK-228
- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-
- 5-(4-aMino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-aMine USP/EP/BP
- MLN0218
- Sapanisertib (NK128
- Sapanisertib (MLN0128)
- 5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyriMidin-3-yl)benzo[d]oxazol-2-amine(INK-128)
- Sapanisertib (INK-128)
- Sapanisertib, 98%, a potent and selective mTOR inhibitor
- Sapanisertib (INK 128, MLN0128)
- MLNO128
- Sapanisertib TAK-228 INK-128 MLN0128 TAK228 INK128
- 3-(2-Ami-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 1224844-38-5
- C15H15N7O
- Inhibitors
- PI3K/Akt/mTOR
- Akt
- mTOR
- PI3K
