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ICA 069673

ICA 069673 Struktur
582323-16-8
CAS-Nr.
582323-16-8
Englisch Name:
ICA 069673
Synonyma:
ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
CBNumber:
CB92552603
Summenformel:
C11H6ClF2N3O
Molgewicht:
269.63
MOL-Datei:
582323-16-8.mol

ICA 069673 Eigenschaften

Siedepunkt:
358.9±37.0 °C(Predicted)
Dichte
1.539±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
Aggregatzustand
Powder
pka
9.47±0.70(Predicted)
Farbe
White to off-white

Sicherheit

ICA 069673 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

ICA 069673 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ICA 069673 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 61)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24727 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
  • ICA 069673
  • N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
  • ICA069673;ICA-069673
  • Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
  • ICA-069673 >=98% (HPLC)
  • Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
  • N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
  • 582323-16-8
  • C11H6ClF2N3O
  • Selective KCNQ2/Q3 potassium channel opener.
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