iCRT 14
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- CAS-Nr.
- 677331-12-3
- Englisch Name:
- iCRT 14
- Synonyma:
- CS-1225;iCRT 14;ICRT14;ICRT-14;iCRT14,iCRT-14,Wnt,Inhibitor,iCRT 14,inhibit;1-[3-(1-hydroperoxy-1-methylethyl)phenyl]-ethanone;5-[[2,5-DiMethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]Methylene]-3-phenyl-2,4-thiazolidinedione;5-((2,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-3-phenylthiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-;(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
- CBNumber:
- CB92546789
- Summenformel:
- C21H17N3O2S
- Molgewicht:
- 375.44
- MOL-Datei:
- 677331-12-3.mol
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iCRT 14 Eigenschaften
- Schmelzpunkt:
- 183-186°C
- Siedepunkt:
- 567.0±60.0 °C(Predicted)
- Dichte
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- pka
- 2.09±0.12(Predicted)
- Farbe
- yellow to orange
- InChIKey
- NCSHZXNGQYSKLR-UNOMPAQXSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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iCRT 14 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Biochem/physiol Actions
iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells.
iCRT 14 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
iCRT 14 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 80)Lieferanten
- iCRT 14
- 5-[[2,5-DiMethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]Methylene]-3-phenyl-2,4-thiazolidinedione
- (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
- CS-1225
- ICRT14;ICRT-14
- 2,4-Thiazolidinedione, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-
- iCRT14,iCRT-14,Wnt,Inhibitor,iCRT 14,inhibit
- 1-[3-(1-hydroperoxy-1-methylethyl)phenyl]-ethanone
- 5-((2,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-3-phenylthiazolidine-2,4-dione
- 677331-12-3
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
