tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
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- CAS-Nr.
- 203661-69-2
- Englisch Name:
- tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
- Synonyma:
- 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;ate tert-butyL;7-Boc-2-oxo-7-azaspiro[3....;7-Boc-2-oxo-7-azaspiro[3.5]nonane;N-Boc-2-oxo-7-azaspiro[3.5]nonane;2-Oxo-7-azaspiro[3.5]nonane-7-carboxyL;7-Azaspiro[3.5]nonan-2-one, N-BOC protected;7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one;ert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate;tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
- CBNumber:
- CB92537657
- Summenformel:
- C13H21NO3
- Molgewicht:
- 239.31
- MOL-Datei:
- 203661-69-2.mol
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tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Eigenschaften
- Schmelzpunkt:
- 55-56℃
- Siedepunkt:
- 349℃
- Dichte
- 1.12
- Flammpunkt:
- 165℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- solid
- pka
- -0.80±0.20(Predicted)
- Farbe
- Clear yellow
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White powder
Synthese
To a flame-dried RB flask with tert-butyl 4-methylenepiperidine-1- carboxylate (2.96 g, 15 mmol, 1.0 equiv) and Zn/Cu couple (6.54 g, 172.5 mmol, 11.5 equiv) under vacuum, t-BuOMe (60 mL) was charged and refilled the flask with N2 balloon. To the mixture thus obtained stirred at 15 °C, a solution of 2,2,2- trichloroacetyl chloride in DME (20 mL) was added dropwise. The mixture was stirred at room temperature overnight after addition. To the reaction mixture stirred in an external ice- bath, a saturated solution of NH4CI (60 mL) was added slowly and carefully (especially the first few drops). After addition, the mixture was stirred at room temperature for 4 h and filtered to remove the solid. The phases were separated. The aqueous phase was extracted with EtOAc. The combined organic phase was washed with brine, dried over anhydrous Na2S04, and concentrated to give the residue, which was purified by CombiFlash (40 g silica gel column, EtOAc/Hexane: 0-40percent) to afford 619 mg (15%) of tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate.
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 163)Lieferanten
- 7-Boc-2-oxo-7-azaspiro[3....
- 7-Boc-2-oxo-7-azaspiro[3.5]nonane
- tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
- 7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one
- 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester
- 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester
- 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester
- 7-Azaspiro[3.5]nonan-2-one, N-BOC protected
- N-Boc-2-oxo-7-azaspiro[3.5]nonane
- ert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
- 2-Oxo-7-aza-spiro3.5none-7-carboxylic acid tert-butyl ester
- 2-Oxo-7-azaspiro[3.5]nonane-7-carboxyL
- ate tert-butyL
- 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester
- 1,1-Dimethylethyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
- 2-oxo-7-azaspiro[3,5]nonane-7-carboxylic tertbytyl ester
- 203661-69-2
- 6203661-69-2
- 03661-69-2
- 203661-89-2
