Ketotifen
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- CAS-Nr.
- 34580-13-7
- Bezeichnung:
- Ketotifen
- Englisch Name:
- KETOTIFEN
- Synonyma:
- hc20-511;HC 20-511;KETOTIFEN;Ketotifeno;idinylidene)-;hiophen-10-one;Ketotifen base;KETOTIFENFUMARATC;Ketotifen Fumaratic;Ketotifen Free Base
- CBNumber:
- CB9249738
- Summenformel:
- C19H19NOS
- Molgewicht:
- 309.43
- MOL-Datei:
- 34580-13-7.mol
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Ketotifen Eigenschaften
- Schmelzpunkt:
- 152-153℃
- Siedepunkt:
- 488.9±45.0 °C(Predicted)
- Dichte
- 1.236
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- 8.84±0.20(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Light Yellow to Orange
- InChI
- InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
- InChIKey
- ZCVMWBYGMWKGHF-UHFFFAOYSA-N
- SMILES
- C12C(=O)CC3=CC=CC=C3/C(=C3/CCN(C)CC/3)/C=1C=CS2
- EPA chemische Informationen
- Ketotifen (34580-13-7)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Ketotifen Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Ketotifen is an intermediate in the synthesis of Ketotifen N-Oxide Hydrochloride (K315410), which is a metabolite of Ketotifen (K315100) in humans; formed by human liver microsome. For the free base, see K315115.
Allgemeine Beschreibung
Crystals (from ethyl acetate).
Brandgefahr
Flash point data for KETOTIFEN are not available. KETOTIFEN is probably combustible.
Clinical Use
Ketotifen is a potent, selective H1 antihistamine that also prevents release of transmitters
from mast cells. It is approved in the United States for topical use to prevent itching of the
eye because of allergic conjunctivitis, It is used as a systemic antiallergy agent in several
countries outside the United States for the treatment of seasonal allergic rhinitis, hay fever,
and asthma. Being structurally analogous to the cyproheptadine-like antihistamines,
differences in activity of the two enantiomers (atropisomers) has been noted, being
approximately six- to seven-fold in ligand displacement and rodent-based assays.
Ketotifen has been shown to stabilize mast cells and to inhibit degranulation of eosinophils.
Like olopatadine, it has been shown to interact with model membranes, stabilizing them by
interaction with phospholipids monolayers.
Ketotifen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ketotifen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 81)Lieferanten
34580-13-7(Ketotifen)Verwandte Suche:
- KETOTIFEN
- 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piper
- 4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
- 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-10h-benzo(4,5)cyclohepta(1,2-b)t
- 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one
- 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
- HC 20-511
- hc20-511
- hiophen-10-one
- idinylidene)-
- Ketotifen Fumaratic
- KETOTIFENFUMARATC
- 4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one
- 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
- Ketotifen base
- Ketotifeno
- 4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one
- Ketotifen Free Base
- 34580-13-7
- C19H19NOS
- API's
