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Domperidone maleate

Domperidone maleate Struktur
99497-03-7
CAS-Nr.
99497-03-7
Englisch Name:
Domperidone maleate
Synonyma:
DOMPERIDONE MALEATE;E-Domperidone Maleate;Domperidone Maleate IP/BP/Ph. Eur;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate;2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate;Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate
CBNumber:
CB9247961
Summenformel:
C26H28ClN5O6
Molgewicht:
541.99
MOL-Datei:
99497-03-7.mol

Domperidone maleate Eigenschaften

storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
L?slichkeit
Very slightly soluble in water, sparingly soluble in dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent).
Aggregatzustand
Solid
Farbe
White to Off-White
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Domperidone maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Domperidone maleate is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Chemische Eigenschaften

Domperidone maleate occurs as a white or almost white powder that exhibits polymorphism. It is very slightly soluble in water or alcohol.

Verwenden

Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

synthetische

Domperidone was synthesized at Janssen Pharmaceutica in 1974 following their research on antipsychotic drugs. The present invention relates to synthesis of domperidone maleate. O-diaminobenzene is first cyclized and halogenated to form the first benzimidazolone intermediate; 1-carbethoxy-4-amino piperidine is halogenated, reduced, cyclized and hydrolyzed to form the second benzimidazolone intermediate; the two benzimidazolone intermediates are reacted to produce domperidone; and domperidone is finally reacted with maleic aicd to produce domperidone maleate.
https://patents.google.com/patent/CN1810805A/en

Indications

Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition.

Domperidone maleate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Domperidone maleate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-0519-85551759 +8613506123987
marketing1@neostarunited.com China 8838 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
sean.lv@synzest.com China 323 58
SINOPRO.CO.LTD
0082-42-721-7177
michael@sinopro.co.kr South Korea 297 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9911 58

99497-03-7()Verwandte Suche:


  • DOMPERIDONE MALEATE
  • 5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate
  • 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate
  • E-Domperidone Maleate
  • 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
  • (E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
  • Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate
  • Domperidone Maleate IP/BP/Ph. Eur
  • 99497-03-7
  • C22H24ClN5O2C4H4O4
  • C26H28ClN5O6
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