CYCLOPIAZONIC ACID
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- CAS-Nr.
- 18172-33-3
- Englisch Name:
- CYCLOPIAZONIC ACID
- Synonyma:
- CPA;CYCLOPIAZONIC ACID;gamma-linolenoyl-CoA;PENICILLIUM CYCLOPIUM;Cyclopiazonic acid,98%;ALPHA CYCLOPIAZONIC ACID;Cyclopiazonic acid (CPA);Penicillium cyclopiumPCR;CYCLOPIAZONICACID,BIOTECHGRADE;Penicillium cyclopium Westling
- CBNumber:
- CB9207176
- Summenformel:
- C20H20N2O3
- Molgewicht:
- 336.38
- MOL-Datei:
- 18172-33-3.mol
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CYCLOPIAZONIC ACID Eigenschaften
- Schmelzpunkt:
- 245-246°C
- Siedepunkt:
- 472.86°C (rough estimate)
- Dichte
- 1.2171 (rough estimate)
- Brechungsindex
- 1.5700 (estimate)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- powder
- pka
- 4.50±1.00(Predicted)
- Farbe
- white to off-white
- Wasserl?slichkeit
- Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
- EPA chemische Informationen
- Cyclopiazonic acid (18172-33-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
36/37/39-45 |
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| RIDADR |
UN 2811 6.1/PG 2 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UY8587000 |
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| HazardClass |
6.1(a) |
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| PackingGroup |
II |
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| HS Code |
29337900 |
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| Giftige Stoffe Daten |
18172-33-3(Hazardous Substances Data) |
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| Toxizit?t |
chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl, |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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CYCLOPIAZONIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Cyclopiazonic acid is a mycotoxin that has been found in
Penicillium and
Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca
2+-ATPase (SERCA; IC
50 = 0.6 μM).
In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD
50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.
Chemische Eigenschaften
off-white powder or crystals
Verwenden
Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.
Allgemeine Beschreibung
Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various
Aspergillus and
Penicillium species.
Biologische Aktivit?t
Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase.
CYCLOPIAZONIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CYCLOPIAZONIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 105)Lieferanten
18172-33-3()Verwandte Suche:
- -Cyclopiazonic acid / CPA
- Cyclopiazonic acid from Penicillium grisefulvum
- Cyclopiazonic acid (CPA)
- Cyclopiazonic acid, FroM PenicilliuM griseofulvuM
- (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
- (6a-alpha,11a,11b-alpha)--10-acetyl-7-dimethyl-11-hydroxy-
- 9h-pyrrolo(1’,2’:2,3)isoindolo(4,5,6-cd)indol-9-one,2,6,6a,7,11a,11b-hexahydro
- (6AA, 10Z, 11AB, 11BA)-6A,7,11A,11B-TETRAHYDRO-10-(1-HYDROXYETHYLIDENE)-7,7- DIMETHYL-6H-PYRROLO [1',2':2,3]ISOINDOLO [4,5,6-CD]INDOLE-9,11 (2H,10H)-DIONE
- (6AR,11AS,11BR)-REL-10-ACETYL-2,6,6A,7,11A,11B-HEXAHYDRO-7,7-DIMETHYL-9H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-9-ONE
- ALPHA CYCLOPIAZONIC ACID
- CPA
- CYCLOPIAZONIC ACID
- CYCLOPIAZONIC ACID, PENICILLIUM CYCLOPIUM
- CYCLOPIAZONIC ACID FROM PENICILLIUMCYCLO PIUM MINIM
- 9H-Pyrrolo1,2:2,3isoindolo4,5,6-cdindol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aR,11aS,11bR)-rel-
- CYCLOPIAZONICACID,BIOTECHGRADE
- [5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-octadeca-6,9,12-trienoylsulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
- gamma-linolenoyl-CoA
- Cyclopiazonic acid from Penicillium cyclopium
- PENICILLIUM CYCLOPIUM
- 10-Acetyl-2,6,6aβ,7,11aα,11bβ-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
- Cyclopiazonic acid,98%
- Cyclopiazonic acid, 98%, from Penicillium griseofulvum
- Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem
- Cyclopiazonic Acid, 98.0+ % (HPLC)
- Penicillium cyclopium Westling
- Penicillium cyclopiumPCR
- 9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aR,11aS,11bR)-
- 18172-33-3
- 181172-33-3
- C20H20N2O3
- C39H64N7O17P3S
- Intracellular Calcium Regulators
- Intracellular Calcium Signaling
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- antibiotic
- Signalling
- Calcium signaling
