4-bromo-2,5-difluorobenzoic acid
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- CAS-Nr.
- 28314-82-1
- Englisch Name:
- 4-bromo-2,5-difluorobenzoic acid
- Synonyma:
- 4-bromo-2,5-difluorobenzoic acid;2,5-Difluoro-4-broMobenzoic acid;Benzoic acid, 4-broMo-2,5-difluoro-;2-Propenoicacid,2-cyano-3-phenyl-,methylester,(5E)-;4-bromo-2,5-difluorobenzoic acid ISO 9001：2015 REACH
- CBNumber:
- CB91559384
- Summenformel:
- C7H3BrF2O2
- Molgewicht:
- 237
- MOL-Datei:
- 28314-82-1.mol
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4-bromo-2,5-difluorobenzoic acid Eigenschaften
- Siedepunkt:
- 285.0±40.0 °C(Predicted)
- Dichte
- 1.872±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.70±0.10(Predicted)
- Aggregatzustand
- wooly powder
- Farbe
- Creamy peach
- InChI
- InChI=1S/C7H3BrF2O2/c8-4-2-5(9)3(7(11)12)1-6(4)10/h1-2H,(H,11,12)
- InChIKey
- YWZSTHLOAZTDFJ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(F)=C(Br)C=C1F
4-bromo-2,5-difluorobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4-Bromo-2,5-difluorobenzoic acid is a synthetic chemical compound that is widely used in scientific research. It is a versatile compound that can be used in many different laboratory experiments. It is also a fluorinated benzoic acid derivative and can be used as a reagent in a variety of organic and inorganic reactions.
Synthese
Freshly titrated n-butyl lithium (27.0 ml, 1.39 M in hexanes) is added slowly (over about 30 minutes) to a -78°C solution of diethyl ether (90 ml) containing 1,4-dibromo-2,5-difluorobenzene (10.22 g, 0.038 mol). The resulting yellow solution is stirred at -78°C for 2 hours to give a yellow suspension. Several pellets (~10) of dry ice are added to the suspension, which is then allowed to warm slowly to room temperature as it degasses (approximately 40 minutes). The resulting suspension is acidified with a 1 M aqueous solution of hydrochloric acid (500 ml), and the product extracted with diethyl ether (5 x 200 ml). The combined organics are washed with water (4 x 100 ml) and filtered. The ether solution is concentrated to approximately 200 ml under reduced pressure, and the product extracted into a saturated aqueous solution of sodium bicarbonate (3 x 200 ml). The combined aqueous extracts are washed with methylene chloride (3 x 100 ml) and acidified with hydrochloric acid. The product is extracted with diethyl ether (3 x 200 ml), and the combined organic extracts washed with water (2 x 200 ml), dried over magnesium sulfate, and concentrated under reduced pressure to give 4-Bromo-2,5-difluorobenzoic acid as a pale yellow solid.
Figure Synthesis of 4-Bromo-2,5-difluorobenzoic acid
4-bromo-2,5-difluorobenzoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-bromo-2,5-difluorobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 144)Lieferanten
28314-82-1()Verwandte Suche:
- 4-bromo-2,5-difluorobenzoic acid
- Benzoic acid, 4-broMo-2,5-difluoro-
- 2,5-Difluoro-4-broMobenzoic acid
- 4-bromo-2,5-difluorobenzoic acid ISO 9001：2015 REACH
- 2-Propenoicacid,2-cyano-3-phenyl-,methylester,(5E)-
- 28314-82-1
