Efaproxiral
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- CAS-Nr.
- 131179-95-8
- Englisch Name:
- Efaproxiral
- Synonyma:
- Efaproxyn;faproxiral;Efaproxiral;EFAPROXIRALUM;Efaproxiral (RSR13);Efaproxiral free acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
- CBNumber:
- CB91359078
- Summenformel:
- C20H22NO4.Na
- Molgewicht:
- 341.4
- MOL-Datei:
- 131179-95-8.mol
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Efaproxiral Eigenschaften
- Schmelzpunkt:
- 48-50°C
- Siedepunkt:
- 554.5±50.0 °C(Predicted)
- Dichte
- 1.202±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 3.26±0.10(Predicted)
- Farbe
- Off-White to Tan
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Efaproxiral Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue. In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O
2) saturation from 48 to 33.8% at a partial oxygen pressure (pO
2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO
2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model. Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg. It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.
Chemische Eigenschaften
Off-White to Tan Solid
Verwenden
Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).
Efaproxiral Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Efaproxiral Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 71)Lieferanten
131179-95-8()Verwandte Suche:
- 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid
- Efaproxiral
- Efaproxiral free acid
- faproxiral
- EFAPROXIRALUM
- 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid
- EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL
- Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
- Efaproxiral (RSR13)
- Efaproxyn
- 131179-95-8
- C20H22NO4Na
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
