epsilon-viniferin
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- CAS-Nr.
- 62218-08-0
- Englisch Name:
- epsilon-viniferin
- Synonyma:
- e-viniferin;Ε-VINIFERIN;ε-Viniferin-RM;epsilon-viniferin;trans-ε-Viniferin;epsilion-Viniferin;ε-Viniferin Standard;(-)-trans-ε-viniferin;(-)-trans-epsilon-viniferin;ε ?Viniferin,ε-?Viniferin,Inhibitor,inhibit,Cytochrome P450,CYPs,ε?Viniferin
- CBNumber:
- CB91337184
- Summenformel:
- C28H22O6
- Molgewicht:
- 454.47
- MOL-Datei:
- 62218-08-0.mol
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epsilon-viniferin Eigenschaften
- Schmelzpunkt:
- approximate 157℃ (dec.)
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble in methanol;
- Aggregatzustand
- Powder
- Farbe
- Off-white to gray
- Wasserl?slichkeit
- sparingly soluble in water
- LogP
- 3.802 (est)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
epsilon-viniferin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
trans-ε-Viniferin is a stilbene polyphenol and dimer of
trans-resveratrol that has been found in various red wines and has diverse biological activities. It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; ) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures.
trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC
50 = 30 nM). It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt.
trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC
50 = ~1 μM).
In vivo,
trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of
trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.
Verwenden
ε-Viniferin is a stilbene extract posessing cytotoxic effects and may contain anti-cancer properties.
epsilon-viniferin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
epsilon-viniferin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 69)Lieferanten
62218-08-0()Verwandte Suche:
- epsilon-viniferin
- (-)-5-[[(2R)-2,3-Dihydro-6-hydroxy-2β-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)vinyl]benzofuran]-3α-yl]-1,3-benzenediol
- (2R)-2β-(4-Hydroxyphenyl)-3α-(3,5-dihydroxyphenyl)-4-(4-hydroxy-trans-styryl)-2,3-dihydrobenzofuran-6-ol
- (2R)-2β-(4-Hydroxyphenyl)-3α-(3,5-dihydroxyphenyl)-4-[(E)-4-hydroxystyryl]-2,3-dihydrobenzofuran-6-ol
- [2R,(-)]-2β-(4-Hydroxyphenyl)-3α-(3,5-dihydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydrobenzofuran-6-ol
- 5-[(2R,3R)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydrobenzofuran-3-yl]benzene-1,3-diol
- e-viniferin
- (-)-trans-epsilon-viniferin
- epsilion-Viniferin
- Ε-VINIFERIN
- ε-Viniferin Standard
- trans-ε-Viniferin
- 1,3-Benzenediol, 5-[(2R,3R)-2,3-dihydro-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-3-benzofuranyl]-
- (-)-trans-ε-viniferin
- 5-[(2R,3R)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol
- ε ?Viniferin,ε-?Viniferin,Inhibitor,inhibit,Cytochrome P450,CYPs,ε?Viniferin
- 5-((2R,3R)-6-Hydroxy-2-(4-hydroxyphenyl)-4-((E)-4-hydroxystyryl)-2,3-dihydrobenzofuran-3-yl)benzene-1,3-diol
- ε-Viniferin-RM
- 62218-08-0
- 62218-08-8