1-Deoxynojirimycin
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- CAS-Nr.
- 19130-96-2
- Englisch Name:
- 1-Deoxynojirimycin
- Synonyma:
- DNJ;moranoline;DEOXYNOJIRIMYCIN;Sepetaprost;Duvoglustat;DNM;S-GI;moranolin;bay-h5595;uvoglusta
- CBNumber:
- CB9128150
- Summenformel:
- C6H13NO4
- Molgewicht:
- 163.17
- MOL-Datei:
- 19130-96-2.mol
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1-Deoxynojirimycin Eigenschaften
- Schmelzpunkt:
- 195-196°C
- Siedepunkt:
- 361.1±42.0 °C(Predicted)
- Dichte
- 1.456±0.06 g/cm3(Predicted)
- Dampfdruck
- 0Pa at 25℃
- RTECS-Nr.
- TN4350300
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in Water up to 25 mg/ml).
- pka
- 13.77±0.70(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White
- Wasserl?slichkeit
- Soluble in water, dimethyl sulfoxide and methanol.
- BRN
- 3588039
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- LogP
- -1.8
- CAS Datenbank
- 19130-96-2(CAS DataBase Reference)
1-Deoxynojirimycin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Crystalline Solid
Occurrence
1-Deoxynojirimycin (DNJ), a product of fermentation, exists in mulberry leaves and Commelina communis (dayflower) as well as is isolated from several bacterial strains such as Bacillus and Streptomyces species. Mulberry, a common deciduous plant, belongs to the genus Morus (Moraceae family). Numerous researchers have reported the DJN contents in different parts and various varieties of mulberry. Various mulberry varieties contain DNJ contents ranging between 0.68 and 2.78 mg/gm, while this fraction varies between 1.57 and 3.48 mg/gm in different Chinese mulberry leaves. Moreover, mulberry shoots contain the highest contents of DNJ, followed by young mulberry leaves. Mature leaves of mulberry contain the least content of DNJ. All the mulberry leave groups showed a 1–2-fold increase in DNJ contents compared to unfermented mulberry leaf powder extract (UFMLE). Additionally, fermented mulberry leaf powder extract exhibited higher α-glucosidase activity than UFMLE. DNJ-rich food products can be prepared by fermenting mulberry leaves using the above-mentioned fermenting agents[6].
Verwenden
An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.
Definition
ChEBI: An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
Biologische Aktivit?t
Inhibitor of glucosidase I (K i = 2.1 mM) and II (K i = 7 mM).
1-Deoxynojirimycin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Deoxynojirimycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 398)Lieferanten
19130-96-2()Verwandte Suche:
Cefalotinnatrium
Natriumdesoxycholat
Oxytetracycline dihydrate
Clindamycin
Droperidol
Gentamicin
[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacen-2-carboxamidmonohydrochlorid
Trichlorethylen
2,2,6,6-Tetramethyl-4-piperidylamin
Chlortetracyclin
Azithromycin
gamma-(4-(p-Chlorphenyl)4-hydroxy-piperidino)-p-fluorbutyrophenon
Diphenoxylat
Piperidin
1,5-Didesoxy-1,5-[(2-hydroxyethyl)imino]-D-glucitol
1,5-Didesoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol
1-Deoxynojirimycin
- (2r,3r,4r,5s)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
- 5-piperidinetriol,2-(hydroxymethyl)-,(2r-(2alpha,3beta,4alpha,5beta))-4
- bay-h5595
- moranolin
- (+)-1-DEOXYNOJIRIMYCIN
- 1-DEOXYNOJIRIMYCIN
- (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL
- (2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
- DNM
- DEOXYNOJIRIMICIN
- 1-DNJ , 1-DEOXYNOJIRIMYCIN
- 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-
- 1-Deoxynojirimycin min. 99%
- 1-DeoxynojiriMycin, froM MorusalbaL.
- 1,5-Dideoxy-1,5-imino-D-sorbitol
- Monoclonal Anti-DNM1 antibody produced in mouse
- 1,5-dideoxy-1,5-imino-d-glucito
- 1,5-dideoxy-1,5-imino-d-glucitol
- 1-deoxynojirimicin
- 1-deoxy-nojirimyci
- 5-amino-1,5-dideoxy-d-glycopyranose
- 5-dideoxy-5-amino-d-glucopyranos
- 5-piperidinetriol(2r-(2alpha,3beta,4alpha,5beta))-2-(hydroxymethyl)-4
- DEOXYNOJIRIMYCIN(SH)
- DESOXYNOJIRIMYCIN
- 1-DEOXYNOJIRIMYCIN,98%
- 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-
- D-Glucitol,-1,5-dideoxy-1,5-imino
- (2R)-3α,4α,5α-Trihydroxypiperidine-2α-methanol
- (2R,3S,4R,5R)-3,4,5-Trihydroxypiperidine-2-methanol
- 1-Deoxy-5-O-aza-D-talopyranose
- 1-Deoxy-D-talo-nojirimycin
- BAY-n-5595
- (2S)-2β-(Hydroxymethyl)-3α,4β,5α-piperidinetriol
- (2S)-3α,4β,5α-Trihydroxypiperidine-2β-methanol
- (3R)-6α-(Hydroxymethyl)piperidine-3β,4α,5β-triol
- 1,5-Dideoxy-1,5-epimino-L-glucitol
- 6α-(Hydroxymethyl)piperidine-3β,4α,5β-triol
- (2R,3R,4R,5S)-2-methylolpiperidine-3,4,5-triol
- 5-AMino-1,5-dideoxy-D-glucopyranose
- Antibiotic S-GI
- S-GI
- 1-Deoxynojirimycin DNJ
- Ramulus Mori
- NojiriMycin, 1-deoxy-
- 1-DeoxynojiriMycin (1-DNJ)
- 1-Deoxynojirimycin, 98%, from MorusalbaL.
- 1-Deoxynojirimycin 1%
- (70956-02-4) 1-deoxynojirimycin
- 1-Deoxynojirimycin 19130-96-2
- Dried mulberry leaves extract/morus alba leaves extract
- 1-Deoxynojirimycin USP/EP/BP
- Miglitol Impurity 3（Deoxynojirimycin）
- 1-Deoxynojirimycin, ≥95%
- moranoline
- DNJ
- DEOXYNOJIRIMYCIN
- Sepetaprost
