Cucurbitacin IIb Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cucurbitacin IIa and cucurbitacin IIb are the characteristic chemical constituents of the hemsleya. Hemsleyadinum are extracted from the Cucurbitaceae, Chrysanthemum, and Hemsleya, which have the function of clearing heat and removing toxicity and antisepsis and anti-inflammation. There are 31 species of Hemsleya in the world, most of which are distributed in China’s Yunnan, Guizhou, and Sichuan provinces, besides the 2 species distributed in India and Vietnam. The main species are H. emiensis, H. pengxianensis, H. amabilis, H. dolichocarpa, H. graciliflora, and H. gigantha . Hemsleya plants are commonly used as Chinese herbal medicines.

Physikalische Eigenschaften

Appearance: rhombohedral or flaky crystals, Solubility: soluble in methanol, ethanol, and acetone, slightly soluble in chloroform, insoluble in water.

History

Hemsleyadinum and hemsloside inhibit Shigella dysenteriae, Salmonella typhimurium, and Salmonella choleraesuis in?vitro. Intravenous injection of cucurbitacin IIa has mild antipyretic effect caused by intraperitoneal injection of typhoid and paratyphoid bacteria but invalid to those with normal body temperature and nonbacterial fever. Xuedansu tablets have significant antitussive effect and show inhibitory effect against p-xylene-induced mouse ear swelling and carrageenaninduced rat toe swelling. Cucurbitacin IIa and cucurbitacin IIb also have anti-HIV-1 activity, which plays a vital role in HIV-1 virus infection . Hemsleyadinum has significant protective effect against acute liver injury caused by CCl4, especially at the high dosage .

Indications

Its dosage forms and indications are available at the Pharmacopoeia of the People’s Republic of China (1977). The current clinical use of hemsleyadinum includes tablets and capsules, which are suitable for bacillary dysentery, enteritis, bronchitis, and acute tonsillitis.

Pharmakologie

The main active ingredient in Cucurbitaceae plants is cucurbitacins, and cucurbitacin IIa and IIb have been used in clinics. Their indications include bacillary dysentery, enteritis, bronchitis, acute tonsillitis, and so on. Cucurbitacin IIa also has anticancer effect . Cucurbitacin IIa (25–100?μM) dose-dependently inhibits proliferation of human lung adenocarcinoma A549 and mouse adenocarcinoma. It blocks the G0/G1 and S phase of A549 cells and thus promotes cell apoptosis . The anticancer mechanism of cucurbitacin IIa is to prevent cancer cell spreading by destroying cytoskeleton of actin and leading to PARP-induced apoptosis by inhibiting production of downstream surviving of JAK/STAT3.

Clinical Use

At present, hemsleyadinum mainly are used as antibacterial and anti-inflammatory drugs, suitable for treatment of upper respiratory tract infection, acute tonsillitis, mumps, pharyngitis, acute and chronic bronchitis, pneumonia etc. Generally speaking, hemsleyadinum and its preparations have less side effects, such as diarrhea, abdominal pain, and other gastrointestinal reactions.

Cucurbitacin IIb Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Cucurbitacin IIb Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253; +8618283602253	jancyzheng@gcgreenpure.com	China	953	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29885	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	4087	58

50298-90-3()Verwandte Suche:

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• Cucurbitacin IIb
• (10α)-2β,3α,16α,20,25-Pentahydroxy-9β-methyl-19-norlanost-5-ene-11,22-dione
• 23,24-Dihydrocucurbitacin F
• Cucurbitacin Ⅱb
• (1S,2S,4R,9β,16α,17ξ)-1,2,16,20,25-pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione
• Hemslecin B
• 19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-
• (2S,3S,8S,9R,10R,13R,14S,16R,17R)-17-[(2R)-2,6-dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one
• cucuritacin IIB
• (2S,3S,8S,9R,10R,13R,14S,16R,17R)-17-((R)-2,6-Dihydroxy-6-methyl-3-oxoheptan-2-yl)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,4,7,8,9,10,12,13,14,15,16,17-tetradecahydro-11H-cyclopenta[a]phenanthren-11-one
• 50298-90-3
• chemical reagent
• pharmaceutical intermediate
• phytochemical
• reference standards from Chinese medicinal herbs (TCM).
• standardized herbal extract