Blonanserin
|
|
|
- CAS-Nr.
- 132810-10-7
- Englisch Name:
- Blonanserin
- Synonyma:
- Lonasen;CS-625;AD 5423;Bunanserin;Bonanserin;Blonanserin;Blonansarin –;Blonanserin IH;Blonanserin >Blonanserin CRS
- CBNumber:
- CB91011174
- Summenformel:
- C23H30FN3
- Molgewicht:
- 367.5
- MOL-Datei:
- 132810-10-7.mol
|
Blonanserin Eigenschaften
- Schmelzpunkt:
- 117-119°C
- Siedepunkt:
- 540.8±50.0 °C(Predicted)
- Dichte
- 1.095±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- pka
- 7.66±0.10(Predicted)
- Farbe
- white to off-white
- Merck
- 14,1319
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22 |
|
|
| WGK Germany |
1 |
|
|
| RTECS-Nr. |
GY0175140 |
|
|
| HS Code |
29339900 |
|
|
| Toxizit?t |
mouse,LD,oral,> 500mg/kg (500mg/kg),United States Patent Document. Vol. #5021421, |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
|
|
|
|
| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
|
Blonanserin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Blonanserin, a dual antagonist of dopamine D2 and serotonin 5-HT2 receptors, was launched past year in Japan for the oral treatment of psychosis and schizophrenia. It is the latest entry in the class of atypical antipsychotic agents to reach the market. Blonanserin exhibits high affinity for D2 and 5-HT2 receptors (IC50 23.6 and 9.85 nM, respectively). Its affinity for D2 receptors is very close to that of haloperidol and risperidone, whereas the affinity for 5-HT2 receptors is about 7 times higher than that of haloperidol and 10 times lower than that of risperidone.Blonanserin is chemically derived in three steps starting with a polyphosphoric acid mediated condensation reaction of cyclooctanone with 4-fluorobenzoylacetonitrile. The resultant 4-fluorophenylcycloocta[b]pyridin-2-one intermediate is converted to the corresponding 2-chloro derivative by treatment with phosphoryl chloride and subsequently condensed with 1-ethylpiperazine to afford blonanserin.
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.
Blonanserin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Blonanserin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 312)Lieferanten
132810-10-7()Verwandte Suche:
- 6-broMo-4,8-dichloro-5-Methoxyquinoline
- Blonansarin –
- Blonanserin, AD-5423, Lonasen
- Blonanserin-d8 HCl
- CYCLOOCTA[B]PYRIDINE, 2-(4-ETHYL-1-PIPERAZINYL)-4-(4-FLUOROPHENYL)-5,6,7,8,9,10-HEXAHYDRO-
- Blonanserin
- AD 5423
- 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
- 2-(4-Ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
- Bunanserin
- Blonanserin, 99.5%, a D2/5-HT2 receptor antagonist
- Blonanserin(AD-5423)
- CS-625
- 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctapyridine
- LONASEN; AD-5423; AD5423; AD 5423
- Blonanserin, 98.0+ % (HPLC)
- Blonanserin Blonanserin
- Blonanserin >
- Blonanserin USP/EP/BP
- Blonanserin Crude
- Lonasen
- Blonanserin IH
- Blonanserin CRS
- Bonanserin
- 132810-10-7
- APIs
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 132810-10-7
