(±)-1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamid
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- CAS-Nr.
- 38396-39-3
- Bezeichnung:
- (±)-1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamid
- Englisch Name:
- (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- Synonyma:
- Bupivacaina;Bucain;Ah 250;Bupivan;Rac-Bupivacaine;Bupivacaine Free Base;Bupivacaine (SKY 0402);Bupivacaine Base
(IHS);Bupivacaine, 10 mM in DMSO;(R,S)-Bupivqacaine hydrochloride
- CBNumber:
- CB8897837
- Summenformel:
- C18H28N2O
- Molgewicht:
- 288.43
- MOL-Datei:
- 38396-39-3.mol
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(±)-1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamid Eigenschaften
- Schmelzpunkt:
- 106-110℃
- Siedepunkt:
- 423.4±45.0 °C(Predicted)
- Dichte
- 1.032±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO:25.0(Max Conc. mg/mL);86.68(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);104.01(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);104.01(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.73(Max Conc. mM)
- pka
- 14.85±0.70(Predicted)
- Aggregatzustand
- Cyrstalline powder
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble in water, ethanol, chloroform (slightly ), and acetone (slightly ).
- EPA chemische Informationen
- 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- (38396-39-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H310 |
Lebensgefahr bei Hautkontakt. |
Acute toxicity,dermal |
Category 1, 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501 |
| H330 |
Lebensgefahr bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501 |
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| Sicherheit |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P320 |
Besondere Behandlung dringend erforderlich |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
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(±)-1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 μM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC
50s = 0.78 and 0.37 mM, respectively). It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 . Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals.
Verwenden
Bupivacaine acts as a potent and long-acting local anesthetic agent in vivo. At 100 μM, it has been reported to inhibit the uptake of dopamine in striatal synaptosomes by 47%.
Definition
ChEBI: A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
(±)-1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(±)-1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 89)Lieferanten
- 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-
- Bupivan
- (R,S)-Bupivqacaine hydrochloride
- rac-(2R*)-N-(2,6-Dimethylphenyl)-1-butyl-2β*-piperidinecarboxamide
- (1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- Ah 250
- Bupivacaine Free Base
- Bucain
- 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboximidic Acid
- BUPIVACAINE FREE BASEBUPIVACAINE FREE BASE
- Rac-Bupivacaine
- Bupivacaine (SKY 0402)
- Bupivacaina
- 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboximidicaci
- Bupivacaine Base
(IHS)
- Bupivacaine, 10 mM in DMSO
- 38396-39-3
