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Etomidolin

etomidoline Struktur
21590-92-1
CAS-Nr.
21590-92-1
Bezeichnung:
Etomidolin
Englisch Name:
etomidoline
Synonyma:
Nonspa;K 2680;Smedolin;Amidoline;etomidoline;Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI);2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one;2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one;1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-
CBNumber:
CB8896360
Summenformel:
C23H29N3O2
Molgewicht:
379.5
MOL-Datei:
21590-92-1.mol

Etomidolin Eigenschaften

Schmelzpunkt:
106-107°
Siedepunkt:
507.34°C (rough estimate)
Dichte
1.1315 (rough estimate)
Brechungsindex
1.6500 (estimate)
pka
8.75±0.10(Predicted)

Sicherheit

Toxizit?t LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971)

Etomidolin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Smedolin,Yamanouchi,Japan,1976

Manufacturing Process

31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol) are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution 5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added and the resulted mixture is heated at 70°C for 1 hour, and then poured into an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)- isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to 104°C) is obtained as a byproduct with the above compound. This latter compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.

Therapeutic Function

Muscle relaxant

Etomidolin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Etomidolin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 4)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19885 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 19704 58

21590-92-1(Etomidolin)Verwandte Suche:


  • etomidoline
  • 1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-
  • Amidoline
  • K 2680
  • Nonspa
  • Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI)
  • Smedolin
  • 2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one
  • 2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one
  • 21590-92-1
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