Pilocarpidin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The leaves of Pilocarpus Jaborandi contain this alkaloid but not those of P.
microphyllus. The alkaloid is a viscous oil which decomposes on attempted
distillation. It has [α]
20D + 81.3° (H20) falling to + 35.2° on the addition of
alkali. The salts are well crystallized and include the hydrochloride which has
[α]~O + 72° (H20); nitrate, m.p. 137°C; [α]
20D + 73.2° (H20); aurichloride, m.p.
125 C and the platinichloride tetrahydrate, m.p. 187°C (dry, dec.). In contrast
to the corresponding salts of pilocarpine and isopilocarpine (q.v.) the picrate is a
non-crystallizable oil. When heated with alkalies, the salts evolve dimethylamine
and on treatment with alcoholic sodium methoxide, the base gives isopilocarpidine, characterized as the nitrate, m.p. 109-111 °C. The latter, on quaternary
methylation furnishes isopilocarpine metho-salts, e.g. the methopicrate, m.p.
119-120°C.
Einzelnachweise
Harnack., Annalen, 238,230 (1887)
Jowett., J. Chem. Soc., 77,474 (1900)
Burtles, Pyman, Roylance., ibid, 127,581 (1925)
Spath, Kunz., Ber., 58,513 (1925)
Preobrashenski et al., ibid, 69, 1837 (1936)
Pilocarpidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte