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Prenylamin

prenylamine Struktur
390-64-7
CAS-Nr.
390-64-7
Bezeichnung:
Prenylamin
Englisch Name:
prenylamine
Synonyma:
B-436;Corpax;Elecor;Segontin;Carditin;Bismethin;SAN 13-194;Hostaginan;prenylamine;Sandoz 13-194
CBNumber:
CB8875291
Summenformel:
C24H27N
Molgewicht:
329.47788
MOL-Datei:
390-64-7.mol

Prenylamin Eigenschaften

Schmelzpunkt:
36.5-37.5°
Siedepunkt:
457.06°C (rough estimate)
Dichte
1.0703 (rough estimate)
Brechungsindex
1.9000 (estimate)
storage temp. 
Refrigerator
L?slichkeit
Chloroform: slightly soluble; Methanol: slightly soluble
Aggregatzustand
A solid
pka
pKa 8.74±0.02(40% EtOH,t =25) (Uncertain)
Farbe
Light yellow to yellow
Wasserl?slichkeit
50mg/L(37 ºC)

Sicherheit

Prenylamin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Prenylamine is a calcium channel inhibitor. It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 μM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 μM, an effect that is negatively associated with the concentration of calmodulin. Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine . Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.

Chemische Eigenschaften

Pale Yellow Oil

Verwenden

Vasodilator (coronary).

Weltgesundheitsorganisation (WHO)

Prenylamine is a calcium-channel blocking agent which was introduced in 1960. It has been widely used for the prophylaxis of angina pectoris and long-term treatment of coronary heart disease. Concern about its propensity to induce dangerous cardiac dysrhythmias led the company to withdraw it from the market.

Prenylamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prenylamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 24)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18070 56
Alfa Chemistry 1-516-6625404
support@alfa-chemistry.com United States 9171 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
sales@rrkchem.com China 57423 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58
Shaanxi Xihua Chemical Industry Co., Ltd 17691182729 13992773979
1049@dideu.com China 8025 58

390-64-7(Prenylamin)Verwandte Suche:


  • 3,3-diphenylpropyl(alpha-methylphenethyl)amine
  • prenylamine
  • DL-PrenylaMine
  • N-(1-Methyl-2-phenylethyl)-γ-phenylbenzenepropanaMine
  • SAN 13-194
  • Sandoz 13-194
  • Segontin
  • Prenylamine (base and/or unspecified salts)
  • B-436
  • Bismethin
  • Carditin
  • Corpax
  • Elecor
  • Hostaginan
  • 3,3-di(phenyl)-N-(1-phenylpropan-2-yl)propan-1-amine
  • 3,3-di(phenyl)propyl-(1-methyl-2-phenyl-ethyl)amine
  • prenylamine USP/EP/BP
  • Benzenepropanamine, N-(1-methyl-2-phenylethyl)-γ-phenyl-
  • 390-64-7
  • C24H27N
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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