Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17,2'(5'H)-furan]-3,5'(2H)-dion, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-Hexadecahydro-10,13-dimethyl-, [6R-(6α,7α,8β,9α,10β,13β,14α,15α,16α,17β)]- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The steroid drospirenone in combination with the estrogen agonist ethinylestradiol was introduced in Germany as a new oral contraceptive for women. This analog of the aldosterone antagonist spironoiactone can be synthesized in five steps from 3β-hydroxy- 15β,16β-methylene-5-androsten-l7-one. Since its binding profile for steroid receptors is very similar to progesterone, drospirenone mimics the progestogen agonistic activity as well as the anti-androgenic and anti-mineralocorticoid properties of the endogenous hormone. In rats, drospirenone inhibited ovulation at 6.3 mglkglday p.o. Compared with currently available progestins which lack anti-mineralocorticoid activity, drospirenone did not cause weight gain that could result from fluid retention in clinical studies. Its combination with ethinylestradiol was well tolerated and did not engender adverse effects on blood pressure or plasma lipid levels. Drospirenone is rapidly absorbed in man with an oral bioavailability of 76%. It is extensively metabolized since over 20 different metabolites were observed in the urine and in the feces, resulting for instance from hydrolysis of the lactone in the plasma or reductive conjugation of the enone to the 3-sulfate ester of 45 dihydrodrospirenone. Its elimination is bi-exponential with an initial and a terminal half-life of 2 and 25-33h respectively.

Chemische Eigenschaften

Off-White Crystalline Powder

Verwenden

Drospirenone has been used as a progestogen agent in pond snail and fish.

Allgemeine Beschreibung

Drospirenone, 3-oxo-6β,7β:15β,16β-dimethylene-17α-pregn-4-en-21,17-carbolactone,differs structurally from all the other commercially availableprogestins. Its structure is similar to that of spironolactone,an MR antagonist, and it does have antimineralocorticoidactivity as well as progestational activity. It isalso reported to have some antiandrogenic effects. Thespirolactone at C17 and the two cyclopropyl groups at C6-C7 and C15-C16 contribute to these unique actions.Drospirenone is the progestin component in the newer oralcontraceptives, Yasmin and Yaz, and in the HRT product,Angeliq.

Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17,2'(5'H)-furan]-3,5'(2H)-dion, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-Hexadecahydro-10,13-dimethyl-, [6R-(6α,7α,8β,9α,10β,13β,14α,15α,16α,17β)]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17,2'(5'H)-furan]-3,5'(2H)-dion, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-Hexadecahydro-10,13-dimethyl-, [6R-(6α,7α,8β,9α,10β,13β,14α,15α,16α,17β)]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
airuikechemical co., ltd.	+undefined86-15315557071	sales02@sdzhonghuimaterial.com	China	983	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12835	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Wuhan Haorong Biotechnology Co.,ltd	+86-18565342920; +8618565342920	sales@chembj.net	China	289	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55

67392-87-4(Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17,2'(5'H)-furan]-3,5'(2H)-dion, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-Hexadecahydro-10,13-dimethyl-, [6R-(6α,7α,8β,9α,10β,13β,14α,15α,16α,17β)]-)Verwandte Suche:

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• 7β-(HydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21,17-carbolactone
• Drospirenone(Dihydrospirorenone)
• Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione
• Drospirenone (USP32)
• Drospirenone, >=98%
• Drosporenone
• 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21
• 6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone
• Drospirenone for peak identification
• 17-beta))-16-alpha
• 6-beta,7-beta
• arbolactone
• ,5’(2h)-dione,1,3’,4’,6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-
• 1,2-dihydrospirorenone
• 15-beta,16-beta-dimethylene-3-oxo-17-alpha-pregn-4-ene-21,17-c
• ZK 3059
• DEHYDROSPIRORENONE
• 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone
• 6,7,15,16-Dimethylene-3-oxo-4-androstene-[17(-1’)-spiro-5’]perhydrofuran-2’-one
• ZK 30595
• dimethyl-,(6r-(6-alpha,7-alpha,8-beta,9-alpha,10-beta,13-beta,14-alpha,15-alph
• spiro(17h-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2’(5’h)-furan)-3
• Drospirenone, USP
• 3-Oxo-6β,7β:15β,16β-diMethylene-17α-pregn-4-en-21,17-carbolactone
• 6b,7b
• 6b,7b,15b,16b-Dimethylene-3-oxo-4-androstene-[17(b-1-spiro-5perhydrofuran-2one
• (6R,17S)-1,3',4',6α,7α,8β,9α,10,11,12,13,14α,15α,16α,20,21-Hexadecahydro-10β,13β-dimethylspiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione
• Dorospirenone
• Drospirenone (200 mg)
• dihydrospirorenone
• DROSPIRENONE
• Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, [6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17b
• 15b,16b-dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone
• Drospirenone-20,20,21,21-d4
• Drospirenone CRS
• Drospirenone>
• Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (2'S,6R,7R,8R,9S,10R,13S,14S,15S,16S)-
• (2'S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,8d,9,9a-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H,4'H)-dione
• Drospirenone USP/EP/BP
• (4aR,4bS,6aS,7S,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-3',4,4a,4b,4',5,6,6a,7a,8,8a,8b,8c,8d,9,9a-hexadecahydro-5'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H)-dione
• Drospirenone D4Q: What is Drospirenone D4 Q: What is the CAS Number of Drospirenone D4 Q: What is the storage condition of Drospirenone D4 Q: What are the applications of Drospirenone D4
• DrospirenoneQ: What is Drospirenone Q: What is the CAS Number of Drospirenone Q: What is the storage condition of Drospirenone Q: What are the applications of Drospirenone
• Drospirenone (1229409)
• 17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone
• DROSPIRENONE INTERMEDIATE
• Drospirenon
• Drospirenona
• Flexor screw ketone
• Drospirenone Estrogen Hormone Raw Powder
• rospirenone
• Spironone
• 1-[1-[4-[4-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-3,6-dihydropyridin-1(2H)-yl]-1-oxobutyl]phenyl]-1,2,3,6-tetrahydropyridin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one.
• Drospirone
• Drospirenone-d4 (3',3',4',4'-d4)
• 5a,7a-dimethyl-1,1a,5,5a,5b,6,7,7a,8a,9,9a,9b,9c,9d-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-8,2'-furan]-3,5'(4H,4'H)-dione
• drospirodone
• 67392-87-4
• 7392-87-4