KU-55933
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- CAS-Nr.
- 587871-26-9
- Englisch Name:
- KU-55933
- Synonyma:
- CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
- CBNumber:
- CB8503709
- Summenformel:
- C21H17NO3S2
- Molgewicht:
- 395.49
- MOL-Datei:
- 587871-26-9.mol
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KU-55933 Eigenschaften
- Siedepunkt:
- 628.0±55.0 °C(Predicted)
- Dichte
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
- pka
- 0.33±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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KU-55933 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.
Biologische Aktivit?t
Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.
Biochem/physiol Actions
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
KU-55933 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
KU-55933 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 154)Lieferanten
587871-26-9()Verwandte Suche:
- 2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE
- 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
- KU-55933 (ATM Kinase Inhibitor)
- KU-55933, >99%
- KV-55933
- 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
- 2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor)
- KU 55933, >=98%
- ATM Kinase Inhibitor
- KU-55933 (ATM KINASE INHIBITOR);KU 55933; KU55933
- U-55933
- CS-63
- KU55933; KU 55933
- KU 55933 NEW
- 4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
- KU-55933 USP/EP/BP
- ATM Kinase Inhibitor Ku-55933 Ku55933
- KU55933,Inhibitor,inhibit,Ataxia telangiectasia mutated,KU-55933,KU 55933,ATM/ATR,ATM and RAD3 related,Autophagy
- KU-55933, competitive ATM kinase inhibitor
- 587871-26-9
- C21H17NO3S2
- Inhibitors
