GAT228 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GAT228 is an allosteric agonist of cannabinoid receptor 1 (CB₁), the R-(+)-enantiomer of the CB₁ positive allosteric modulator (PAM) GAT229 , and a component of the racemic mixture GAT211, which acts as both an agonist and PAM. GAT228 increases β-arrestin recruitment, cAMP inhibition, and ERK1/2 and PLCβ3 phosphorylation in HEK293A cells expressing GFP-tagged human CB₁ (hCB₁-GFP) in a concentration-dependent manner. Unlike GAT229, GAT228 has no effect on the binding of the CB receptor agonist CP 55,940 to membranes from CHO cells expressing hCB₁ when used at concentrations up to 1 μM. It inhibits excitatory postsynaptic currents (EPSCs) in a subset of CB₁-expressing murine autaptic hippocampal neurons when used at a concentration of 1 μM.

GAT228 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GAT228 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8617	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9272	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19711	58

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• GAT228
• GAT228 >=98% (HPLC)
• 1H-Indole, 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-
• 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole
• 1446648-15-2