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Histrelin

Histrelin Struktur
76712-82-8
CAS-Nr.
76712-82-8
Englisch Name:
Histrelin
Synonyma:
histrelin acetate;PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET;1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-;N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly;orf17070;Supprelin;RWJ-17070;HISTRELIN;Amyridine;Histreline Acetate
CBNumber:
CB8480046
Summenformel:
C66H86N18O12
Molgewicht:
1323.53
MOL-Datei:
76712-82-8.mol

Histrelin Eigenschaften

alpha 
D20 -33.9° (c = 1 in acetic acid)
Dichte
1.46±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
powder
pka
9.82±0.15(Predicted)
Stabilit?t:
Hygroscopic
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 60
S-S?tze: 53-22-36/37/39-45
WGK Germany  3
RTECS-Nr. OK6370800
HS Code  3504009000
Giftige Stoffe Daten 76712-82-8(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Histrelin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.

Verwenden

LHRH agonist.

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

Histrelin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Histrelin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 139)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634
Cecilia@youngshechem.com China 2345 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10310 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 1000 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12837 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32038 58

76712-82-8()Verwandte Suche:


  • Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
  • 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
  • RWJ-17070
  • Supprelin
  • 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
  • Histreline Acetate
  • ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
  • (n-ethyl-l-prolinamide)-10-deglycinamide-
  • 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
  • orf17070
  • PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
  • PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET
  • (HIS(BZL)6)-HISTRELIN
  • HISTRELIN
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
  • [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
  • Histrelin USP/EP/BP
  • Histrelin Acetate(net)
  • 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
  • PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
  • histrelin acetate
  • N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly
  • Amyridine
  • 76712-82-8
  • C66H86N18O12
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • Peptides
  • Releasing Factors
  • LH-RH
  • hormones
  • Peptide
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