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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Struktur
251310-57-3
CAS-Nr.
251310-57-3
Englisch Name:
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
Synonyma:
TR ANTAGONIST 1-850;THYROID HORMONE RECEPTOR ANTAGONIST, 1-850;1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea;2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE;Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
CBNumber:
CB8468369
Summenformel:
C21H20F3N5O4
Molgewicht:
463.41
MOL-Datei:
Mol file

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Eigenschaften

Dichte
1.464±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
≤0.5mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
Aggregatzustand
crystalline solid
pka
9.75±0.43(Predicted)

Sicherheit

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
  • TR ANTAGONIST 1-850
  • 2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE
  • 1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea
  • Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
  • 251310-57-3
  • C21H20F3N5O4
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