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Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz)

PEPLOMYCIN SULFATE Struktur
70384-29-1
CAS-Nr.
70384-29-1
Bezeichnung:
Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz)
Englisch Name:
PEPLOMYCIN SULFATE
Synonyma:
Pepleo;NK 631;Nsc276382;PEPLOMYCIN SULFATE;Pepleomycin Sulfate;N1-[3-[[(1S)-1-phenylethyl]aMino]propyl]bleoMycinaMide;N1-[3-[[(1S)-1-phenylethyl]amino]propyl]bleomycinamide Sulfate;Bleomycinamide, N1-[3-[(1-phenylethyl)amino]propyl]-, (S)-, sulfate (1:1) (salt)
CBNumber:
CB8413187
Summenformel:
C61H90N18O25S3
Molgewicht:
1571.67
MOL-Datei:
70384-29-1.mol

Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz) Eigenschaften

Schmelzpunkt:
196-198°C
alpha 
25436 -2.0° (c = 1 in water)
L?slichkeit
DMSO, DMF, Methanol, Water
Aggregatzustand
Powder
pka
2.9, 4.8, 7.4, 9.0(at 25℃)
Farbe
Pale Yellow Amorphous

Sicherheit

Toxizit?t LD50 in male rats, mice (mg/kg): 234, 88 s.c.; 208, 85 i.p.; 245, 51 i.v. (Ito)

Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Peplomycin was derived biosynthetically from Streptomyces verticillus, the bleomycinproducing organism, in the course of efforts to obtain bleomycin derivatives with high activity and low toxicity. This antibiotic was found by Nippon Kayaku Co. and the Institute of Microbial Chemistry, Japan, in 1974. Its anticancer effects appear earlier than those of bleomycin; consequently, the period of therapy is shortened. Peplomycin is also active against metastatic cancer of the lymph nodes and shows less pneumotoxicity than bleomycin.

Chemische Eigenschaften

Pale Yellow Amorphous Powder

Sicherheitsprofil

Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Schwefelsure

Downstream Produkte

Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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70384-29-1(Bleomycinamid, N1-[3-[(1-Phenylethyl)amino]propyl]-, (S)-, Sulfat (1:1) (Salz))Verwandte Suche:

  • PEPLOMYCIN SULFATE
  • Bleomycinamide, N1-[3-[(1-phenylethyl)amino]propyl]-, (S)-, sulfate (1:1) (salt)
  • N1-[3-[[(1S)-1-phenylethyl]amino]propyl]bleomycinamide Sulfate
  • NK 631
  • Pepleo
  • Pepleomycin Sulfate
  • Nsc276382
  • N1-[3-[[(1S)-1-phenylethyl]aMino]propyl]bleoMycinaMide
  • 70384-29-1
  • C61H90N18O25S3
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
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