Hirudin
|
|
|
- CAS-Nr.
- 8001-27-2
- Bezeichnung:
- Hirudin
- Englisch Name:
- HIRUDIN
- Synonyma:
- hirudex;NATIVE HIRUDIN;DESULFO-HIRUDIN;DESULFATO-HIRUDIN;recombinanthirudin;HIRUDIN RECOMBINANT;hirudin from leeches;[TYR63]HIRUDIN (HV1), LEECH;Hirudin recombinant from yeast;[63-TYROSINE]HIRUDIN (HV1), LEECH
- CBNumber:
- CB8399669
- Summenformel:
- C287H440N80O113S7
- Molgewicht:
- 7043.4877
- MOL-Datei:
- 8001-27-2.mol
|
Hirudin Eigenschaften
- storage temp.
- 2-8°C
- Aggregatzustand
- lyophilized powder
- Farbe
- white
- Merck
- 13,4737
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
22-24/25 |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
MR8440000 |
|
|
| F |
10-21 |
|
|
| HS Code |
3504009000 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
|
Hirudin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Refludan was launched in Germany for heparin-associated
thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis),
the gene for recombinant hirudin was synthesized and expressed in Saccharomyces
cerevisiae. The isolated protein is 65 amino acids differing from the native protein by
the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain
the three disulfide bonds. Refludan is a potent, specific and almost irreversible
inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds
to the active catalytic site of thrombin, while the C-terminal end binds to the anion
binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it
can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ
as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is
a pure, single compound with a single mechanism of action. It is useful for myocardial
infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited
by platelets activated by the Fc fragment of antibodies developed to the antigen of
heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.
Verwenden
Recombinant hirudin from yeast has been used in mannan-binding lectin serine protease 2 (MASP2) activation assay. It has also been used in pre-treating the nanosheets in phosphate buffered saline (PBS) for platelet adhesion assay.
Allgemeine Beschreibung
Hirudin is a 7 kDa acidic protein containing 65 amino acid residues that has an isoelectric point of 3.5-4.0. It is not glycosylated and lacks tryptophan, arginine and methionine residues. It is chemically stable between pH 2-12 and at temperatures up to 80°C.
Hirudin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Hirudin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 79)Lieferanten
8001-27-2(Hirudin)Verwandte Suche:
- hirudex
- recombinanthirudin
- HIRUDIN RECOMBINANT
- DESULFATO-HIRUDIN
- DESULFO-HIRUDIN
- NATIVE HIRUDIN
- [TYR63]HIRUDIN (HV1), LEECH
- (63-tyrosine)hirudin (hv1),leech,rec. F. yeast
- [Tyr63]Hirudin (HV1), leech recombinant, from yeast
- hirudin from leeches
- Hirudin recombinant from yeast
- Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces Cere
- [63-tyrosine]hirudin (HV1), leech recombinant
- [63-TYROSINE]HIRUDIN (HV1), LEECH
- [63-Tyrosine]Hirudin (HV1), leech, Desulfato-hirudin, Desulfo-hirudin
- Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces cerevisiae - CAS 8001-27-2 - Calbiochem
- 8001-27-2
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Type
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors
- R to Z
- Proteins
- Biochemicals and Reagents
- BioChemical
- Coagulation Proteins and ReagentsPlasma&Blood Proteins
- HirudinProtease Inhibitors
- Plasma&Blood Proteins
- Plasma, Blood, and Related Proteins and Reagents
- Protease Inhibitor Specificity Index
- Proteins and Derivatives
- R to
- Thrombin
- ThrombinEnzyme Inhibitors by Enzyme
- proteins
