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Amodiachin

Amodiaquine Struktur
86-42-0
CAS-Nr.
86-42-0
Bezeichnung:
Amodiachin
Englisch Name:
Amodiaquine
Synonyma:
CAM-AQI;CAM-AQ1;Miaquin;Camoquin;Camochin;Camoquine;SN 10,751;NSC 13453;Camoquinal;Flavoquine
CBNumber:
CB8344720
Summenformel:
C20H22ClN3O
Molgewicht:
355.86
MOL-Datei:
86-42-0.mol

Amodiachin Eigenschaften

Schmelzpunkt:
208°C
Siedepunkt:
478.0±45.0 °C(Predicted)
Dichte
1.258
storage temp. 
-20°C Freezer
L?slichkeit
DMSO (Slightly, Sonicated), Methanol (Slightly)
Aggregatzustand
Solid
pka
9.43±0.50(Predicted)
Farbe
Pale Yellow to Light Yellow
CAS Datenbank
86-42-0(CAS DataBase Reference)
NIST chemische Informationen
Amodiaquine(86-42-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Giftige Stoffe Daten 86-42-0(Hazardous Substances Data)
Toxizit?t LD50 oral in mouse: 550mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Amodiachin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine . It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.

Chemische Eigenschaften

Cyrstalline Solid

Verwenden

An antimalarial

Definition

ChEBI: A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.

Indications

Amodiaquine (Camoquin) is another 4-aminoquinoline derivative whose antimalarial spectrum and adverse reactions are similar to those of chloroquine, although chloroquine-resistant parasites may not be amodiaquine- resistant to the same degree. Prolonged treatment with amodiaquine may result in pigmentation of the palate, nail beds, and skin. There is a 1:2000 risk of agranulocytosis and hepatocellular dysfunction when the drug is used prophylactically.

Weltgesundheitsorganisation (WHO)

Amodiaquine, an antimalarial agent related to chloroquine, was introduced over 40 years ago for the treatment and prophylaxis of malaria. The drug was voluntarily withdrawn in the United Kingdom in 1975 for commercial reasons but was subsequently reintroduced in 1985 to meet the medical demand for an antimalarial drug to deal with the rapid spread of chloroquine-resistant falciparum malaria in Asia and Africa. By 1986 a significant number of cases of agranulocytosis associated with prophylactic use, some of which were fatal, had been reported there and it has been estimated that the frequency of this risk is of the order of 1:2,000. Although most cases occurred when amodiaquine had been used in combination with other antimalarials, the major manufacturer decided to withdraw the prophylactic indication worldwide following discussions with experts. Preparations remain available for the treatment of acute attacks of malaria which involves only a short period of exposure to the drug. (Reference: (WHODI) WHO Drug Information, 1, 5, 1987)

Pharmazeutische Anwendungen

A mono-Mannich-base 4-aminoquinoline, formulated as the dihydrochloride dihydrate or free base for oral administration. It is active against P. falciparum and P. vivax and is more active than chloroquine for the treatment of uncomplicated P. falciparum malaria. Chloroquine-resistant strains may remain susceptible, but resistance to amodiaquine is also spreading in some regions of Africa. The pharmacological properties are similar to those of chloroquine. The terminal elimination halflife is 1–3 weeks. It is rapidly and extensively metabolized to the desethyl derivative which has reduced antiplasmodial activity. Prophylactic use has been abandoned because of agranulocytosis and hepatotoxicity due to formation of a quinoneimine metabolite. A fixed dose combination with artesunate and derivatives (for example, isoquine) with altered metabolism and reduced toxicity is in development.

Clinical Use

Mechanistically, it is very similar to chloroquine and does nothave any advantages over the other 4-aminoquinoline drugs.When used for prophylaxis of malaria, it had a higher incidenceof hepatitis and agranulocytosis than that was chloroquine.There is evidence that the hydroquinone (phenol)amine system readily oxidizes to a quinone imine either autoxidatively and/or metabolically, and this productmay contribute to amodiaquine’s toxicity.

l?uterung methode

Amodiaquin crystallises from 2-ethoxyethanol or EtOH. [Burckhalter et al. J Am Chem Soc 70 1363 1948, Beilstein 22 III/IV 4647.]

Amodiachin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Amodiachin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 126)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
zhangjiagang vinsce bio-pharm. limited.
86-512-58389969
sales1@swellxin.com CHINA 111 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32079 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34553 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58

86-42-0(Amodiachin)Verwandte Suche:


  • 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-creso
  • 4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol
  • 4-[(7-Chloro-4-quinolinyl)amino]-alpha-(diethylamino)-o-cresol
  • 7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline
  • Amodiaquine, ring-closed
  • CAM-AQ1
  • CAM-AQI
  • Camochin
  • Camoquin
  • Camoquinal
  • Camoquine
  • Flavoquine
  • Miaquin
  • o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-
  • Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-
  • Quinoline, 7-chloro-4-((3-((diethylamino)methyl)-4-hydroxyphenyl)amino)-
  • S. N. 10751
  • SN 10,751
  • 7-chloro-4-(3-diethylaminomethyl-4-hydroxyanilino)quinoline
  • AMODIAQUIN
  • AMODIAQUINE
  • 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-phenol
  • Amodiaquine USP24
  • 4-[3'-Dimethyl-aminomethyl-4'-hydroxyanilino]-7-chloroquinoline
  • 4-[7-Chloro-4-quinolylamino]-α-diethylamino-o-cresol
  • 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol, SN-10751
  • Amodiaquine (base and/or unspecified salts)
  • 4-[(7-Chloro-4-quinolynyl)amino]-2-[(diethylamino)methyl]phenol
  • 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
  • 4-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol
  • DRUGS: AMODIAQUINE USP
  • NSC 13453
  • Amodiaquine USP/EP/BP
  • AmodiaquineQ: What is Amodiaquine Q: What is the CAS Number of Amodiaquine Q: What is the storage condition of Amodiaquine Q: What are the applications of Amodiaquine
  • Amodiaquine 150-200 mg Tablet
  • AMODIQUINE BASE
  • 86-42-0
  • C20H12ClN3OD10
  • C20H22ClN3O
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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