Dolasetron mesylate
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- CAS-Nr.
- 115956-13-3
- Englisch Name:
- Dolasetron mesylate
- Synonyma:
- anzemet;mdl73147ef;Anzemet hydrate;DOLASETRON MESYLATE;Dalasetron (Mesylate);Dolasetron Mesylate USP;Dolasetron Mesylate hydrate;Dolasetron Mesylate (200 mg);DOLASETRON MESYLATE MONHYDATE;dolasetronmesylatemonohydrate
- CBNumber:
- CB8341693
- Summenformel:
- C20H26N2O7S
- Molgewicht:
- 438.49
- MOL-Datei:
- 115956-13-3.mol
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Dolasetron mesylate Eigenschaften
- Schmelzpunkt:
- 278°
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- H2O: >30mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- CAS Datenbank
- 115956-13-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Dolasetron mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dolasetron was launched as Anzemet in Australia and the US for the
prevention of nausea and vomiting in chemotherapy patients. It is a highly potent
and very selective antagonist of 5-HT3 receptors ; it is the sixth in this class of
compounds to be marketed for the treatment of chemotherapy-induced emesis.
The last two approved in this class were Nazasetron (1994) and Ramosetron
(1996). Anzemet was prepared by a seven step sequence from a
cyclopentenecarboxylic ester via a Robinson-Schopf cyclisation of a dialdehyde
into a key 9-azabicyclo[3.3.l]nonan-3-one. In a clinical study with 164 cancer
patients treated with Dolasetron mesylate prior to Cisplatin, single doses of 10-
50 mg achieved major control of nausea and emesis in 73% of subjects and
were well tolerated. Results from pharmacokinetic studies in humans showed
that the clinical effects and duration of action seem to be due mainly to a major
plasma metabolite rapidly formed and very potent itself, the (+) enantiomeric
alcohol obtained by enzymatic reduction of the cyclic ketone.
Verwenden
Dolasetron Mesylate acts as a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Dolasetron mesylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dolasetron mesylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 158)Lieferanten
115956-13-3()Verwandte Suche:
- DOLASETRON MESYLATE:DOLASETRON
- Dolasetron mesylate／(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate
- (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate
- Dolasetron Mesylate (200 mg)
- Dolasetron Mesylate hydrate
- Dalasetron (Mesylate)
- Anzemet hydrate
- Dolasetron methanesulfonate hydrate
- Dolasetron Mesylate USP
- DOLASETRON MESYLATE
- DOLASETRON MESYLATE MONHYDATE
- 1h-indole-3-carboxylicacid,octahydro-3-oxo-2,6-methano-2h-quinolizin-8-ylest
- dolasetronmesylatemonohydrate
- er,(2-alpha,6-alpha,8-alpha,9a-beta)-,monomethanesulfonate,monohydrate
- mdl73147ef
- Dolasetron mesylate (MDL73147)
- Dolasetron mesylate USP/EP/BP
- 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
- anzemet
- Anzemet hydrate|||MDL-73147EF
- 115956-13-3
- 15956-13-3
- 115953-13-3
- C20H26N2O7S
- C19H20N2O3CH4O3SH2O
- C20H24N2O6S
- C19H20N2O3CH4O3S
- API
- Other APIs
- Antiemetic
