AX-024 hydrochloride
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- CAS-Nr.
- 1704801-24-0
- Englisch Name:
- AX-024 hydrochloride
- Synonyma:
- AX-024;AX-024;AX024;AX 024;AX-024 hydrochloride;AX-024 hydrochloride, 10 mM in DMSO;1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride;AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
- CBNumber:
- CB83364105
- Summenformel:
- C21H23ClFNO2
- Molgewicht:
- 375.87
- MOL-Datei:
- 1704801-24-0.mol
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AX-024 hydrochloride Eigenschaften
- storage temp.
- -20°
- L?slichkeit
- Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
- Aggregatzustand
- solid
- Farbe
- White
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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AX-024 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
AX-024 is an inhibitor of the CD3ε-Nck interaction. It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC
50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4
+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG
35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox).
AX-024 hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
AX-024 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 60)Lieferanten
- AX-024;AX024;AX 024
- AX-024 hydrochloride
- AX-024
- 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride
- AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
- AX-024 hydrochloride, 10 mM in DMSO
- 1704801-24-0
