ML 351
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- CAS-Nr.
- 847163-28-4
- Englisch Name:
- ML 351
- Synonyma:
- ML 351;5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile;5-(Methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile;4-Oxazolecarbonitrile, 5-(methylamino)-2-(1-naphthalenyl)-;Subarachnoid hemorrhage,inhibit,oxidative stress,ML-351,SAH,neuronal,Lipoxygenase,LOX,T1D,β-cell,ML 351,ML351,Inhibitor,non-obese diabetic
- CBNumber:
- CB83146332
- Summenformel:
- C15H11N3O
- Molgewicht:
- 249.27
- MOL-Datei:
- 847163-28-4.mol
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ML 351 Eigenschaften
- Siedepunkt:
- 507.3±60.0 °C(Predicted)
- Dichte
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- ≤5mg/ml in DMSO;25mg/ml in dimethyl formamide
- pka
- -0.97±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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ML 351 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. ML351 is an inhibitor of human reticulocyte 15-LO-1 (IC
50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2. ML351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an
in vivo mouse model for ischemic stroke.
Verwenden
ML351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.
Biochem/physiol Actions
ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.
ML 351 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ML 351 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 44)Lieferanten
- ML 351
- 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
- 4-Oxazolecarbonitrile, 5-(methylamino)-2-(1-naphthalenyl)-
- Subarachnoid hemorrhage,inhibit,oxidative stress,ML-351,SAH,neuronal,Lipoxygenase,LOX,T1D,β-cell,ML 351,ML351,Inhibitor,non-obese diabetic
- 5-(Methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile
- 847163-28-4
