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1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Struktur
34823-86-4
CAS-Nr.
34823-86-4
Englisch Name:
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
Synonyma:
GTP-14564;3-PHENYL-1H-BENZOFURO[3,2-C]PYRAZOLE;1H-Benzofuro[3,2-c]pyrazole, 3-phenyl-;1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
CBNumber:
CB8298108
Summenformel:
C15H10N2O
Molgewicht:
234.25
MOL-Datei:
34823-86-4.mol

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Eigenschaften

Schmelzpunkt:
222-223 °C
Siedepunkt:
459.1±25.0 °C(Predicted)
Dichte
1.321±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 1 mg/ml
Aggregatzustand
A crystalline solid
pka
12.72±0.30(Predicted)
Farbe
Off-white to yellow

Sicherheit

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 μM for c-Fms, c-Kit, ITD-FLT3 and 1 μM for PDGFRβ). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.

Verwenden

GTP 14564 is a class III receptor tyrosine kinase (RTK) inhibitor.

Biologische Aktivit?t

Potent, selective inhibitor of class III receptor tyrosine kinases (IC 50 values are 0.3 μ M for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μ M for PDGFR β ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μ M). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic.

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 46)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 4604 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613
 sales@chemrenpharm.com China 3600 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761
 486064515@qq.com China 3642 58
Hefei Mokai Pharmaceutical Technology Co., Ltd 18130062233
 3362556465@qq.com China 7999 58
  • GTP-14564
  • 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
  • 3-PHENYL-1H-BENZOFURO[3,2-C]PYRAZOLE
  • 1H-Benzofuro[3,2-c]pyrazole, 3-phenyl-
  • 34823-86-4
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