ADIPORON
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- CAS-Nr.
- 924416-43-3
- Englisch Name:
- ADIPORON
- Synonyma:
- CS-918;104890;AdipiRon;AdipoRon;SC-396658;AdipoR agonist;AdipoRon (SC-396658);924416-43-3, CFCD924416433,;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
- CBNumber:
- CB82681793
- Summenformel:
- C27H28N2O3
- Molgewicht:
- 428.52
- MOL-Datei:
- 924416-43-3.mol
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ADIPORON Eigenschaften
- Schmelzpunkt:
- 106-108°C
- Siedepunkt:
- 645.3±55.0 °C(Predicted)
- Dichte
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- pka
- 13.92±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
ADIPORON Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with K
D values of 1.8 and 3.1 μM, respectively. At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-
fat diet and in genetically obese
db/db mice.
Biochem/physiol Actions
AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.
ADIPORON Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ADIPORON Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 123)Lieferanten
924416-43-3()Verwandte Suche:
- SC-396658
- AdipoRon
- 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide
- 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
- 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide AdipoRon
- AdipoR agonist
- AdipiRon
- ACETAMIDE, 2-(4-BENZOYLPHENOXY)-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]-
- 104890
- CS-918
- 924416-43-3, CFCD924416433,
- AdipoRon (SC-396658)
- 924416-43-3
- Inhibitors
- API
