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NDT 9513727

NDT 9513727 Struktur
439571-48-9
CAS-Nr.
439571-48-9
Englisch Name:
NDT 9513727
Synonyma:
NDT 9513727;N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine;1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-;Bis[(2H-1,3-benzodioxol-5-yl)methyl][(1-butyl-2,4-diphenyl-1H-imidazol-5-yl)methyl]amine
CBNumber:
CB82603001
Summenformel:
C36H35N3O4
Molgewicht:
573.68
MOL-Datei:
439571-48-9.mol

NDT 9513727 Eigenschaften

Siedepunkt:
723.1±62.0 °C(Predicted)
Dichte
1.23±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO: 100 mM; Ethanol: 100 mM
Aggregatzustand
A solid
pka
6.69±0.50(Predicted)
Farbe
White to yellow

Sicherheit

NDT 9513727 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NDT 9513727 is a competitive antagonist of the C5a receptor (C5aR; IC50 = 11.6 nM for human recombinant receptors) that has inverse agonist activity in a GTPγ[35S] assay. It is selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 μM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively). NDT 9513727 inhibits degranulation in U937 cells stimulated with C5a (IC50 = 7.1 nM). It also prevents neutropenia induced by human recombinant C5a in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques when administered at doses of 5 and 25 mg/kg.

Verwenden

NDT 9513727 is a selective, and potent inverse agonist of the human C5aR. NDT 9513727 has been shown to effectively inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo. These results suggest that NDT 9513727 is a promising candidate for the treatment of human inflammatory diseases.

NDT 9513727 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NDT 9513727 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 36)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 94657 76
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
info@tsbiochem.com China 8065 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
 sales-cpd@caerulumpharma.com China 3466 58
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2990 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088
 3193328036@qq.com China 29764 68
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
 sales@rrkchem.com China 57423 58
  • NDT 9513727
  • N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine
  • 1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
  • Bis[(2H-1,3-benzodioxol-5-yl)methyl][(1-butyl-2,4-diphenyl-1H-imidazol-5-yl)methyl]amine
  • 439571-48-9
  • Agonist, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
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