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CAY10526

CAY10526 Struktur
938069-71-7
CAS-Nr.
938069-71-7
Englisch Name:
CAY10526
Synonyma:
CAY10526;CAY10526 Exclusive;CAY10526, 10 mM in DMSO;2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-;3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one;WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase
CBNumber:
CB82590422
Summenformel:
C12H7BrO3S
Molgewicht:
311.15
MOL-Datei:
938069-71-7.mol

CAY10526 Eigenschaften

Siedepunkt:
561.7±50.0 °C(Predicted)
Dichte
1.889±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
Aggregatzustand
A crystalline solid
pka
8.90±0.60(Predicted)
Farbe
Off-white to yellow

Sicherheit

CAY10526 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 μM without any effect on COX-2 expression.

CAY10526 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CAY10526 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 52)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2998 58
Biokitchen 021-021-021-31663258 13795219287
 donghuanwen@126.com China 9970 58
  • CAY10526
  • CAY10526 Exclusive
  • 3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one
  • 2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-
  • WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase
  • 4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one
  • CAY10526, 10 mM in DMSO
  • 938069-71-7
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