N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
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- CAS-Nr.
- 53501-41-0
- Englisch Name:
- N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
- Synonyma:
- PIT 1;N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide;N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide;Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
- CBNumber:
- CB82518929
- Summenformel:
- C14H10ClN3O4S
- Molgewicht:
- 351.76
- MOL-Datei:
- 53501-41-0.mol
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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Eigenschaften
- Dichte
- 1.592
- storage temp.
- Store at +4°C
- L?slichkeit
- DMSO: ≥14mg/mL
- Aggregatzustand
- powder
- pka
- 4.44±0.50(Predicted)
- Farbe
- white to tan
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
PtdIns-
(3,4,5)-
P
3 (PIP
3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-
kinase (PI3K) or PTEN. Protein binding to PIP
3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-
1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP
3/Akt PH domain binding with an IC
50 value of 31 μM. PIT-
1 suppresses PI3K-
PDK1-
Akt-
dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-
deficient U87MG glioblastoma cells (IC
50 = 37 μM).
Verwenden
PIT 1 is an apoptosis inducing selective PIP3 antagonist.
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
- N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
- PIT 1
- Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
- N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide
- 53501-41-0
- C14H10ClN3O4S
