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Ruxolitinib phosphate

Ruxolitinib phosphate Struktur
1092939-17-7
CAS-Nr.
1092939-17-7
Englisch Name:
Ruxolitinib phosphate
Synonyma:
INC424;INCB 018424;INC 424 phosphate;Ruxotinib phosphate;Rusotinib phosphate;Jakafi (ruxolitinib);IINCB018424 phosphate;Ruxolitinib, Phosphate;INCB018424 (phosphate);10-dimethoxyptercarpan
CBNumber:
CB82509943
Summenformel:
C17H21N6O4P
Molgewicht:
404.37
MOL-Datei:
1092939-17-7.mol

Ruxolitinib phosphate Eigenschaften

Schmelzpunkt:
186-190°C
storage temp. 
Refrigerator
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/s3
InChIKey
JFMWPOCYMYGEDM-AVAJOTNLNA-N
SMILES
P(O)(O)(O)=O.[C@@H](C1CCCC1)(N1N=CC(C2N=CN=C3NC=CC=23)=C1)CC#N |&1:5,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  29331990
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Ruxolitinib phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.

Definition

ChEBI: A phosphate salt obtained by reaction ruxolitinib with one equivalent of phosphoric acid. Used for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essent al thrombocythemia myelofibrosis.

Clinical Use

Ruxolitinib phosphate is a potent, selective, ATP competitive inhibitor of tyrosine-protein kinases JAK1 and JAK2 which acts by attenuating cytokine signaling and promotes apoptosis. Ruxolitinib was discovered and developed by Incyte, is marketed under the brand name Jakafi,and is approved for the treatment of patients with myelofibrosis (MF), including primary MF, post-polycythemia vera MP, and post-essential thrombocythemia MF. Ruxolitinib is also undergoing clinical evaluation against a wide variety of cancer indications including metastatic prostate cancer, pancreatic cancer, multiple myeloma, leukemia, non-Hodgkin lymphoma, and breast cancer. Additionally, ruxolitinib is being evaluated for the treatment of psoriasis and thrombocytopenia.

Ruxolitinib phosphate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ruxolitinib phosphate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 324)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.
+86-0311-67591193 +8613931880626
sales02@dingminpharma.com China 252 58
Protheragen-ING
+16313385890
info@protheragen-ing.com United States 3868 58
SICHUAN XIELI PHARMACEUTICAL CO.,LTD.
+86-028-60118998 +8615830127659
sales7@xielipharm.com China 24 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 456 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55

  • (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
  • INCB 018424
  • Ruxolitinib, Phosphate Salt
  • Ruxolitinib, Phosphate
  • (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate
  • (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid
  • Ruxolitinib (INCB-18424) phosphate
  • Jakafi (ruxolitinib)
  • Ruxolitinib phosphate, >=98%
  • (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
  • RUXOLITINIB(INCB018424) PHOSPHATE
  • Ruxotinib phosphate
  • Ruxolitinib phosphate(INCB018424)
  • Beta-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(Betar)-1H-pyrazole-1-propanenitrile, phosphate
  • (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosph
  • INCB 018424(Ruxolitinib Phosphate)
  • INCB 018424 (phosphate)
  • INCB018424 (phosphate)
  • INCB-018424 (phosphate)
  • (R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
  • INCB018424;INCB-018424;INCB 018424
  • INCB018424 PHOSPHATE;INCB 018424 PHOSPHATE;INCB-018424 PHOSPHATE;RUXOLITINIB
  • RUXOLITINIB PHOSPHATE (INCB018424 PHOSPHATE)
  • INC 424 phosphate
  • Ruxolitinib phosphate ISO 9001:2015 REACH
  • Ruxolitinib Phosphate (INC-424, INCB-18424, INCB-018424, Jakafi and Jakavi)
  • phosphenoperoxoic acid compound with (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile and dihydrogen (1:1:1)
  • (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
  • 10-dimethoxyptercarpan
  • INC424
  • IINCB018424 phosphate
  • (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
  • Rusotinib phosphate
  • 1092939-17-7
  • C17H18N6H3PO4
  • C17H21N6O4P
  • Intracellular signaling.
  • Inhibitors
  • Antineoplastic
  • API
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