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(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid

(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid Struktur
39391-39-4
CAS-Nr.
39391-39-4
Englisch Name:
(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid
Synonyma:
FR-1923;FR-1923C;Nocardicin A;Antibiotic FR-1923;(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid;(3S,αR)-3β-[[[4-[(3R)-3-Amino-3-carboxypropoxy]phenyl][(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid;(αR,3S)-3-[[(2Z)-2-[4-[(3R)-3-AMino-3-carboxypropoxy]phenyl]-2-(hydroxyiMino)acetyl]aMino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic Acid;1-Azetidineacetic acid, 3-[[(2Z)-2-[4-[(3R)-3-amino-3-carboxypropoxy]phenyl]-2-(hydroxyimino)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-, (αR,3S)-
CBNumber:
CB82367671
Summenformel:
C23H24N4O9
Molgewicht:
500.45806
MOL-Datei:
39391-39-4.mol

(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid Eigenschaften

Schmelzpunkt:
214-216° (dec)
alpha 
D25 -135° (for the sodium salt)
Siedepunkt:
591.34°C (rough estimate)
Dichte
1.4360 (rough estimate)
Brechungsindex
1.6500 (estimate)
pka
2.18±0.10(Predicted)
Farbe
Needles

Sicherheit

Toxizit?t LD50 in male mice, rats (mg/kg): >8000 orally; >2000 i.v.; 2500, 2600 i.p. (Aoki)

(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Nocardicin A is a β-lactam antibiotic.

Sicherheitsprofil

Moderately toxic byintraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.

(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • FR-1923C
  • Nocardicin A
  • (αR,3S)-3-[[(2Z)-2-[4-[(3R)-3-AMino-3-carboxypropoxy]phenyl]-2-(hydroxyiMino)acetyl]aMino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic Acid
  • (3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]-[(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid
  • (3S,αR)-3β-[[[4-[(3R)-3-Amino-3-carboxypropoxy]phenyl][(Z)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid
  • Antibiotic FR-1923
  • FR-1923
  • 1-Azetidineacetic acid, 3-[[(2Z)-2-[4-[(3R)-3-amino-3-carboxypropoxy]phenyl]-2-(hydroxyimino)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-, (αR,3S)-
  • 39391-39-4
  • C23H24N4O9
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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