Anti-S. cerevisiae, HOMOLOG-LIKE 1, Anti-SIR2α, Anti-SIR2, Anti-SIR2L1, Anti-Sirtuin 1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Rabbit polyclonal anti-SIRT1 antibody is used to tag sirtuin-1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of sirtuin-1 in NAD
(+) status-dependent energy homeostasis at the level of nuclear transcription control and protein deacetylation.
Allgemeine Beschreibung
Sirtuin (silent mating type information regulation 2 homolog) 1
(S. cerevisiae) (SIRT1), a member of the NAD
(+)-dependent protein deacetylase SIRT family, is involved in the regulation of nuclear transcription of genes involve in energy metabolism. SIRT1 provides a link between cellular energy status sensing (NAD
(+) status) and the regulation of energy homoeostasis. SIRT1 is involved in the regulation of metabolism, cell differentiation and senescence, stress response, and cancer.
Biochem/physiol Actions
Sirtuin 1 is a protein encoded by the SIRT1 gene in humans. It is a class III histone deacetylase. It plays an important role in biological functions (such as lifespan, stress, and inflammation) through deacetylation of histone and nonhistone proteins. This gene is involved in the chondrogenic development of mesenchymal stem cells (MSCs). It may be associated with the progression of colorectal cancer.
Anti-S. cerevisiae, HOMOLOG-LIKE 1, Anti-SIR2α, Anti-SIR2, Anti-SIR2L1, Anti-Sirtuin 1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
